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Titolo:
A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus (JCV) in a tissue culture model: Implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy
Autore:
Atwood, WJ;
Indirizzi:
Brown Univ, Dept Mol Microbiol & Immunol, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 ol & Immunol, Providence, RI 02912 USA
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 4, volume: 7, anno: 2001,
pagine: 307 - 310
SICI:
1355-0284(200108)7:4<307:ACOLCA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL GLIAL-CELLS; MULTIPLICATION; RECEPTOR; INFECTION;
Keywords:
central nervous system; drug therapy; JC virus; phenothiazines; progressive multifocal leukoencephalopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Atwood, WJ Brown Univ, Dept Mol Microbiol & Immunol, 69 Brown St,Box G-B616, Providence, RI 02912 USA Brown Univ 69 Brown St,Box G-B616 Providence RIUSA 02912 2 USA
Citazione:
W.J. Atwood, "A combination of low-dose chlorpromazine and neutralizing antibodies inhibits the spread of JC virus (JCV) in a tissue culture model: Implications for prophylactic and therapeutic treatment of progressive multifocal leukencephalopathy", J NEUROVIRO, 7(4), 2001, pp. 307-310

Abstract

The human polyomavirus, JCV, is the etiologic agent of a fatal central nervous system (CNS) demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML occurs predominantly in immunosuppressed patients and remains an intractable complication in AIDS. To date, there are no effective therapies to treat PML. We previously demonstrated that the neuroleptic drug, chlorpromazine, inhibits the endocytic pathway used by JCV to infect glial cells. In this paper, we demonstrate that nontoxic doses of chlorpromazine are effective at inhibiting JCV multiplication and spread in a tissue culture model. The clinical efficacy of this drug or related compounds in treating PML has not been evaluated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 17:44:41