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Titolo:
A classification scheme for human polyomavirus JCV variants based on the nucleotide sequence of the noncoding regulatory region
Autore:
Jensen, PN; Major, EO;
Indirizzi:
NINCDS, Lab Mol Med & Neurosci, NIH, Bethesda, MD 20892 USA NINCDS Bethesda MD USA 20892 Med & Neurosci, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 4, volume: 7, anno: 2001,
pagine: 280 - 287
SICI:
1355-0284(200108)7:4<280:ACSFHP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; VIRUS-DNA SEQUENCE; GLIAL-CELLS; T-ANTIGEN; TRANSCRIPTIONAL ACTIVATION; CEREBROSPINAL-FLUID; HUMAN BRAIN; HOST RANGE; KAPPA-B; EXPRESSION;
Keywords:
JCV; regulatory region; nucleotide sequence; classification scheme; pathogenesis; progressive multifocal leukoencephalopathy (PML);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Major, EO NINCDS, Lab Mol Med & Neurosci, NIH, Bldg 36,Room 5W21, Bethesda, MD 20892USA NINCDS Bldg 36,Room 5W21 Bethesda MD USA 20892 esda, MD 20892USA
Citazione:
P.N. Jensen e E.O. Major, "A classification scheme for human polyomavirus JCV variants based on the nucleotide sequence of the noncoding regulatory region", J NEUROVIRO, 7(4), 2001, pp. 280-287

Abstract

The human polyomavirus JCV is responsible for the central nervous system (CNS) demyelination observed in cases of progressive multifocal leukoencephalopathy (PML). Lytic infection of oligodendrocytes, the cells that constitute the basis of myelin in the CNS, is established by JCV in conjunction with immunosuppressive conditions. Beyond this, however, many questions related to JCV pathogenesis remain unanswered. The JCV regulatory region is a hypervariable noncoding sequence positioned between the early and late protein-coding regions. The particular nucleotide sequence of a JCV regulatory region affects levels of viral transcription and replication. Modifications tothis promoter/enhancer structure can alter the cellular host range and maybe responsible for switching JCV between states of lytic and latent infection. The regulatory region structure has, therefore, been used to distinguish JCV variants. Nucleotide sequencing studies have uncovered numerous variations of regulatory region structure. Until now, however, no inclusive nomenclature existed that linked variants by regulatory region structure and/or activity We have arranged all known variant JCV regulatory regions into quadrants according to the integration of particular sequence sections and repetition of sequence section groups. This arrangement of regulatory regions results in an updated nomenclature that is well-suited for describing therelationships between JCV variants. Four distinct structural forms (I-S, I-R, II-S, and II-R) are defined along with tissue tropisms. This design provides logical connections between the variant regulatory regions and may beuseful for elucidating crucial steps in JCV pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:23:51