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Titolo:
Quantitative response characteristics of thermoreceptive and nociceptive lamina I spinothalamic neurons in the cat
Autore:
Craig, AD; Krout, K; Andrew, D;
Indirizzi:
Barrow Neurol Inst, Div Neurosurg, Atkinson Pain Res Lab, Phoenix, AZ 85013 USA Barrow Neurol Inst Phoenix AZ USA 85013 in Res Lab, Phoenix, AZ 85013 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 3, volume: 86, anno: 2001,
pagine: 1459 - 1480
SICI:
0022-3077(200109)86:3<1459:QRCOTA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDULLARY DORSAL HORN; HIGH-THRESHOLD MECHANORECEPTORS; NOXIOUS MECHANICAL STIMULATION; INNOCUOUS COLD DISCRIMINATION; TRIGEMINAL-NUCLEUS-CAUDALIS; CENTRAL NERVOUS-SYSTEM; EVOKED CUTANEOUS PAIN; PRIMATE SPINAL-CORD; C-FIBER NOCICEPTORS; BODY SITE VARIATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Craig, AD Barrow Neurol Inst, Div Neurosurg, Atkinson Pain Res Lab, 350 W Thomas Rd,Phoenix, AZ 85013 USA Barrow Neurol Inst 350 W Thomas Rd Phoenix AZ USA 85013 5013 USA
Citazione:
A.D. Craig et al., "Quantitative response characteristics of thermoreceptive and nociceptive lamina I spinothalamic neurons in the cat", J NEUROPHYS, 86(3), 2001, pp. 1459-1480

Abstract

The physiological characteristics of antidromically identified lamina I spinothalamic (STT) neurons in the lumbosacral spinal cord were examined using quantitative thermal and mechanical stimuli in barbiturate-anesthetized cats. Cells belonging to the three main recognized classes were included based on categorization with natural cutaneous stimulation of the hindpaw: nociceptive-specific (NS), polymodal nociceptive (HPC), or thermoreceptive-specific (COOL) cells. The mean central conduction latencies of these classes differed significantly; NS = 130.8 +/- 55.5 (SD) ms (n = 100), HPC = 72.1 +/- 28.0 ms (n = 128), and COOL = 58.6 +/- 25.3 ms (n = 136), which correspond to conduction velocities of 2.5, 4.6, and 5.6 m/s. Based on recordings made prior to any noxious stimulation, the mean spontaneous discharge rates of these classes also differed: NS = 0.5 +/- 0.7 imp/s (n = 47), HPC = 0.9 /- 0.7 imp/s (n = 59), and COOL = 3.3 +/- 2.6 imp/s (n = 107). Standard, quantitative, thermal stimulus sequences applied with a Peltier thermode were used to characterize the stimulus-response functions of 76 COOL cells, 47HPC cells, and 37 NS cells. The COOL cells showed a very linear output from 34 degreesC down to similar to 15 degreesC and a maintained plateau thereafter. The HPC cells showed a fairly linear but accelerating response to cold below a median threshold of similar to 24 degreesC and down to 9 degreesC (measured at the skin-thermode interface with a thermode temperature of 2degreesC). The HPC cells and the NS cells both showed rapidly increasing, sigmoidal response functions to noxious heat with a fairly linear response between 45 and 53 degreesC, but they had significantly different thresholds; half of the HPC cells were activated at similar to 45.5 degreesC and halfof the NS cells at similar to 43 degreesC. The 20 HPC lamina I STT cells and 10 NS cells tested with quantitative pinch stimuli showed fairly linear responses above a threshold of similar to 130 g/mm(2) for HPC cells and a threshold of similar to 100 g/mm(2) for NS cells. All of these response functions compare well (across species) with the available data on the characteristics of thermoreceptive and nociceptive primary afferent fibers and the appropriate psychophysics in humans. Together these results support the concept that these classes of lamina I STT cells provide discrete sensory channels for the sensations of temperature and pain.

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Documento generato il 19/09/20 alle ore 15:25:23