Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of NMDA, non-NMDA, and GABA receptors in signal propagation in the amygdala formation
Autore:
Wang, C; Wilson, WA; Moore, SD;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27705 USA Duke Univ DurhamNC USA 27705 d Ctr, Dept Pharmacol, Durham, NC 27705 USA Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27705 USA Duke Univ Durham NC USA 27705 ed Ctr, Dept Psychiat, Durham, NC 27705 USA Durham Vet Adm Med Ctr, Div Psychiat, Durham, NC 27705 USA Durham Vet Adm Med Ctr Durham NC USA 27705 Psychiat, Durham, NC 27705 USA Durham Vet Adm Med Ctr, Div Neurol, Durham, NC 27705 USA Durham Vet Adm Med Ctr Durham NC USA 27705 v Neurol, Durham, NC 27705 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 3, volume: 86, anno: 2001,
pagine: 1422 - 1429
SICI:
0022-3077(200109)86:3<1422:RONNAG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM SLICES; BASOLATERAL AMYGDALA; INHIBITORY TRANSMISSION; EPILEPTIFORM ACTIVITY; RAT AMYGDALA; FEAR; NEURONS; ACTIVATION; RESPONSES; ANXIETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, C Durham Vet Adm Med Ctr, Div Neurol, Rm 31,Bldg 16,508 Fulton St, Durham, NC 27705 USA Durham Vet Adm Med Ctr Rm 31,Bldg 16,508 Fulton St Durham NC USA 27705
Citazione:
C. Wang et al., "Role of NMDA, non-NMDA, and GABA receptors in signal propagation in the amygdala formation", J NEUROPHYS, 86(3), 2001, pp. 1422-1429

Abstract

Although the synaptic physiology of the amygdala has been studied with single neuron recordings, the properties of the networks between the various nuclei have resisted characterization because of the limitations of field recording in a neuronally diffuse structure. We addressed this issue in the rat amygdala complex in vitro by using a photodiode array coupled with a voltage-sensitive dye. Low-intensity single pulse stimulation of the lateral amygdala nucleus produced a complex multiphasic potential. This signal propagated to the basolateral nucleus and the amygdalostriatal transition zone but not to the central nucleus. The local potential, which depended on both synaptic responses and activation of voltage-dependent ion channels, was reduced in amplitude by the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor antagonist 6,7-dinitroquinoxaline (DNQX) and reduced to a lesser extent by the NMDA glutamate, receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV). We next characterized the less complex signals that propagated to more distal regions with or without the addition of the GABA receptor antagonist bicuculline, (BIC). BIC alone greatly increased the signal propagation and permitted activation of previously silent areas within the amygdala. DNQX blocked signal propagation to amygdala regions outside of La, even in the presence of BIC, whereas D-APV had minimal effects on these distalsignals. These data represent several novel findings: the, characterization of the multi-component potential near the site of stimulation, the gatingof signal propagation within the amygdala by GABAergic inhibition, the critical role of non-NMDA receptor-mediated depolarization in signal propagation, and the lack of a role for NMDA receptors in maintaining propagation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:08:00