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Titolo:
Chronic high dose L-dopa treatment does not alter the levels of dopamine D-1, D-2 or D-3 receptor in the striatum of normal monkeys: an autoradiographic study
Autore:
Zeng, BY; Pearce, RKB; MacKenzie, GM; Jenner, P;
Indirizzi:
Univ London Kings Coll, Guys Kings & St Thomas Sch Biomed Sci, Neurodegenerat Dis Res Ctr, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL r, London SE1 1UL, England
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 8-9, volume: 108, anno: 2001,
pagine: 925 - 941
SICI:
0300-9564(2001)108:8-9<925:CHDLTD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEVODOPA-INDUCED DYSKINESIA; MESSENGER-RNA EXPRESSION; PARKINSONS-DISEASE PATIENTS; BASAL GANGLIA; MPTP-MONKEYS; GENE-EXPRESSION; MACACA-FASCICULARIS; GABA(A) RECEPTORS; GLOBUS-PALLIDUS; COMMON MARMOSET;
Keywords:
L-dopa; dyskinesia; primates; dopamine D-1, D-2 and D-3 receptors; autoradiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Jenner, P Univ London Kings Coll, Guys Kings & St Thomas Sch Biomed Sci, Neurodegenerat Dis Res Ctr, Hodgkin Bldg,Guys Campus, London SE1 1UL, England Univ London Kings Coll Hodgkin Bldg,Guys Campus London England SE1 1UL
Citazione:
B.Y. Zeng et al., "Chronic high dose L-dopa treatment does not alter the levels of dopamine D-1, D-2 or D-3 receptor in the striatum of normal monkeys: an autoradiographic study", J NEURAL TR, 108(8-9), 2001, pp. 925-941

Abstract

To assess the role of dopamine receptors in the genesis of dyskinesia, we have used quantitative autoradiography to determine the effect of chronic L-dopa administration on dopamine D-1 (using [H-3]SCH 23390), D-2 (using [H-3]spiperone) and D-3 (using [H-3]7-OH-DPAT) receptor binding levels in the striatum of dyskinetic or non-dyskinetic monkeys. Total and subregional striatal analysis showed no difference in D-1, D-2 or D-3 receptor binding in the caudate and putamen between monkeys receiving high dose L-dopa treatment with marked dyskinesia and those without dyskinesia compared to untreatedanimals. It thus appears unlikely that changes in dopamine receptor expression are a primary cause Of L-dopa induced dyskinesia. Rather, a functionaldissociation of D-2 receptor coupling to co-expressed enkephalin/adenosine-2a receptor activity in the striato-GPe indirect pathway may be more important in the development or expression Of L-dopa-induced involuntary movements.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:59:57