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Titolo:
Glutamate is not involved in the MPP+-induced dopamine overflow in the striatum of freely moving C57BL/6 mice
Autore:
Uezono, T; Matsubara, K; Shimizu, K; Mizukami, H; Ogawa, K; Saito, O; Hayase, N; Eto, H; Kimura, K; Shiono, H;
Indirizzi:
Asahikawa Med Coll, Dept Legal Med, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan Asahikawa Med Coll, Dept Pharm & Pharmacol, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan Shimane Med Univ, Dept Legal Med, Izumo, Shimane 693, Japan Shimane Med Univ Izumo Shimane Japan 693 l Med, Izumo, Shimane 693, Japan
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 8-9, volume: 108, anno: 2001,
pagine: 899 - 908
SICI:
0300-9564(2001)108:8-9<899:GINIIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
1-METHYL-4-PHENYLPYRIDINIUM MPP+; EXTRACELLULAR CONCENTRATIONS; PARKINSONS-DISEASE; MK-801 FAILS; ASPARTATE; MPTP; TRANSPORTER; METABOLITE; RELEASE; NEURONS;
Keywords:
MPP+; dopamine overflow; NMDA antagonist; glutamate; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Matsubara, K Asahikawa Med Coll, Dept Hosp Pharm & Pharmacol, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 07885100, Japan
Citazione:
T. Uezono et al., "Glutamate is not involved in the MPP+-induced dopamine overflow in the striatum of freely moving C57BL/6 mice", J NEURAL TR, 108(8-9), 2001, pp. 899-908

Abstract

The role of glutamate in the N-methyl-4-phenyl-dihydropyridinium (MPP+) toxicity has been argued in the past decade. However, the effects of glutamate efflux and NMDA antagonist on MPP+-induced dopamine overflow have not been documented. To clarify this, we perfused MPP+ through a microdialysis probe in the striatum of freely moving mature C57BL/6 mice. The 60-min perfusion of 10 and 100 muM MPP+ strikingly increased dopamine levels to 28- and 93-fold of the basal values, respectively. In contrast, an administration ofMPP+ did not induce marked glutamate release: the MPP+-perfusion slightly increased the glutamate level at 100 muM, but not at 10 muM. The addition of 100 muM (+)-MK-801 or 200 muM (+/-)-AP-7 to the perfusate did not attenuate MPP+-induced dopamine overflow. The extent of dopamine release only depended on the amount of MPP+ accumulation into the cells. These results indicated that, at least in the striatum, neither glutamate release nor the NMDAantagonist, including (+)-MK-801, could regulate MPP+-evoked dopamine overflow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:30:52