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Titolo:
Serotonin blockade does not affect nonarticular tenderness in healthy volunteers
Autore:
Ben-Zion, IZ; Meiri, G; Shiber, A; Buskila, D; Benjamin, J;
Indirizzi:
Ben Gurion Univ Negev, Fac Hlth Sci, Kupat Holim Sick Fund, Soroka Med Ctr,Rheumat Dis Unit, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel at Dis Unit, Beer Sheva, Israel Ben Gurion Univ Negev, Fac Hlth Sci, Kupat Holim Sick Fund, Soroka Med Ctr,Dept Psychiat, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel pt Psychiat, Beer Sheva, Israel
Titolo Testata:
JOURNAL OF MUSCULOSKELETAL PAIN
fascicolo: 3, volume: 9, anno: 2001,
pagine: 43 - 49
SICI:
1058-2452(2001)9:3<43:SBDNAN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; FIBROSITIS SYNDROME; M-CHLOROPHENYLPIPERAZINE; FIBROMYALGIA SYNDROME; RHEUMATOID-ARTHRITIS; PAIN THRESHOLD; SYMPTOMS; RAT; METERGOLINE; ANTAGONIST;
Keywords:
serotonin; tenderness; dolorimetry; pain; metergoline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ben-Zion, IZ Ben Gurion Univ Negev, Fac Hlth Sci, Kupat Holim Sick Fund, Soroka Med Ctr,Dept Psychiat, Beer Sheva, Israel Ben Gurion Univ Negev BeerSheva Israel Beer Sheva, Israel
Citazione:
I.Z. Ben-Zion et al., "Serotonin blockade does not affect nonarticular tenderness in healthy volunteers", J MUSCULO P, 9(3), 2001, pp. 43-49

Abstract

Objectives: To investigate the role of serotonergic pathways as a potential factor modulating pain in general and nonarticular tenderness in particular. Methods: Twenty healthy volunteers were given metergoline [a nonspecific serotonin blocker] once and placebo once, in a double blind, placebo-controlled, randomized crossover design. The administrations were separated by at least one week. In each session a count of 18 tender points was conducted by thumb palpation just before and 90 minutes after capsule ingestion. Tenderness of nine of the tender points as well as four control points was further assessed with a Chatillon dolorimeter. Results: There was no significant difference in the point count or in tenderness in the presence or absence of serotonin blockade. Conclusions: Serotonin blockade in healthy individuals has no effect on the point count or on tender point sensitivity. This suggests that involvement of serotonergic pathways does not contribute to pain syndromes associatedwith nonarticular tenderness, or, alternatively, that studies of nonarticular tenderness in healthy volunteers are not relevant to the same phenomenon in clinical syndromes. (C) 2001 by The Haworth Press, Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:24:21