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Titolo:
Isolation and biological activity of frankiamide
Autore:
Haansuu, JP; Klika, KD; Soderholm, PP; Ovcharenko, VV; Pihlaja, K; Haahtela, KK; Vuorela, PM;
Indirizzi:
Univ Helsinki, Vlikki Drug Discovery Technol Ctr, Dept Pharm, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 rm, FIN-00014 Helsinki, Finland Univ Helsinki, Vlikki Drug Discovery Technol Ctr, Dept Pharm, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 rm, FIN-00014 Helsinki, Finland Univ Helsinki, Div Pharmacognosy, Dept Pharm, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 rm, FIN-00014 Helsinki, Finland Univ Helsinki, Dept Chem, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 em, FIN-00014 Helsinki, Finland Univ Helsinki, Dept Biosci, Div Gen Microbiol, FIN-00014 Helsinki, FinlandUniv Helsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland
Titolo Testata:
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
fascicolo: 1, volume: 27, anno: 2001,
pagine: 62 - 66
SICI:
1367-5435(200107)27:1<62:IABAOF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETULA-PENDULA; STRAINS; GROWTH; BACTERIA; SOILS;
Keywords:
Frankia; antibiotic; frankiamide; calcium antagonist; GH(4)C(1) rat pituitary cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Vuorela, PM Univ Helsinki, Vlikki Drug Discovery Technol Ctr, Dept Pharm, POB 56, FIN-00014 Helsinki, Finland Univ Helsinki POB 56 Helsinki Finland FIN-00014 inki, Finland
Citazione:
J.P. Haansuu et al., "Isolation and biological activity of frankiamide", J IND MIC B, 27(1), 2001, pp. 62-66

Abstract

An antibiotic produced by the symbiotic actinomycete Frankia strain AiPs1 was isolated from culture broth using optimized thin-layer chromatography and high-performance liquid chromatography (HPI-C) methods. The novel compound that was isolated, dubbed frankiamide, displayed antimicrobial activity against all 14 Gram-positive bacterial strains and six pathogenic fungal strains tested. The pathogenic actinomycete Clavibacter michiganensis and theooymycete Phytophthora were especially susceptible. In addition to displaying antimicrobial activity, frankiamide also strongly inhibited Ca-45(2+) fluxes in clonal rat pituitary GH(4)C(1) tumor cells and was comparable to afrequently used calcium antagonist, verapamil hydrochloride. The results of HPLC analysis, supported by both nuclear magnetic resonance and mass spectroscopy studies, showed that frankiamide has a high affinity for Na+ ions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 13:39:57