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Titolo:
Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
Autore:
Iellem, A; Mariani, M; Lang, R; Recalde, H; Panina-Bordignon, P; Simigaglia, F; DAmbrosio, D;
Indirizzi:
Roche Milano Ric, I-20132 Milan, Italy Roche Milano Ric Milan Italy I-20132 he Milano Ric, I-20132 Milan, Italy Ctr Trasfus, I-20013 Magenta, Italy Ctr Trasfus Magenta Italy I-20013Ctr Trasfus, I-20013 Magenta, Italy
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 6, volume: 194, anno: 2001,
pagine: 847 - 853
SICI:
0022-1007(20010917)194:6<847:UCRPAS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOCYTE-ASSOCIATED ANTIGEN-4; IMMUNOLOGICAL SELF-TOLERANCE; UP-REGULATION; TH2 CELLS; INFLAMMATION; ACTIVATION; EFFECTOR; SUBSETS; AGONIST; (CCR)8;
Keywords:
chemokines; lymphocyte homing; cytokines; T lymphocyte subsets; immunosuppression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: D'Ambrosio, D Roche Milano Ric, V Olgettina 58, I-20132 Milan, Italy RocheMilano Ric V Olgettina 58 Milan Italy I-20132 , Italy
Citazione:
A. Iellem et al., "Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells", J EXP MED, 194(6), 2001, pp. 847-853

Abstract

Chemokines dictate regional trafficking of functionally distinct T cell subsets. In rodents and humans, a unique subset of CD4(+)CD25(+) cytotoxic T lymphocyte antigen (CTLA)-4(+) regulatory T cells (Treg) has been proposed to control peripheral tolerance. However, the molecular basis of immune suppression and the trafficking properties of Treg cells are still unknown. Here, we determined the chemotactic response profile and chemokine receptor expression of human blood-borne CD4(+)CD25(+) Treg cells. These Treg cells were found to vigorously respond to several inflammatory and lymphoid chemokines. Treg cells specifically express the chemokine receptors CCR4 and CCR8and represent a major subset of circulating CD4(+) T cells responding to the chemokines macrophage-derived chemokine (MDC)/CCL22, thymus and activation-regulated chemokine (TARC)/CCL17, I-309/CCL1, and to the virokine vMIP-1(ligands of CCR4 and CCR8). Blood-borne CD4(+) T cells that migrate in response to CCL1 and CCL22 exhibit a reduced alloproliferative response, dependent on the increased frequency of Treg cells in the migrated population. Importantly, mature dendritic cells preferentially attract Treg cells among circulating CD4(+) T cells, by secretion of CCR4 ligands CCL17 and CCL22. Overall, these results suggest that CCR4 and/or CCR8 may guide Treg cells tosites of antigen presentation in secondary lymphoid tissues and inflamed areas to attenuate T cell activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 09:41:51