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Titolo:
Evidence for reactive nitrogen species formation in the gingivomucosal tissue
Autore:
Lohinai, Z; Stachlewitz, R; Virag, L; Szekely, AD; Hasko, G; Szabo, C;
Indirizzi:
Semmelweis Univ, Inst Human Physiol & Clin Expt Res, Budapest, Hungary Semmelweis Univ Budapest Hungary iol & Clin Expt Res, Budapest, Hungary Semmelweis Univ, Dept Anat, Budapest, Hungary Semmelweis Univ Budapest Hungary eis Univ, Dept Anat, Budapest, Hungary Inotek Corp, Beverly, MA 01915 USA Inotek Corp Beverly MA USA 01915Inotek Corp, Beverly, MA 01915 USA
Titolo Testata:
JOURNAL OF DENTAL RESEARCH
fascicolo: 2, volume: 80, anno: 2001,
pagine: 470 - 475
SICI:
0022-0345(200102)80:2<470:EFRNSF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; TYROSINE NITRATION; PORPHYROMONAS-GINGIVALIS; PEROXYNITRITE FORMATION; SUPEROXIDE-DISMUTASE; PERIODONTAL-DISEASE; IN-VIVO; NITROTYROSINE; MACROPHAGES; MERCAPTOETHYLGUANIDINE;
Keywords:
reactive nitrogen species; nitrating species; nitric oxide; peroxynitrite; nitrotyrosine; inducible nitric oxide synthase; periodontal disease; gingiva; tooth bud; maxillary sinus; gastrointestinal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lohinai, Z 78-A Ullou Ut, H-1082 Budapest, Hungary 78-A Ullou Ut Budapest Hungary H-1082 -1082 Budapest, Hungary
Citazione:
Z. Lohinai et al., "Evidence for reactive nitrogen species formation in the gingivomucosal tissue", J DENT RES, 80(2), 2001, pp. 470-475

Abstract

An increase in nitric oxide production has been demonstrated in periodontitis. Here we investigated the potential role of nitric-oxide-derived nitrating species (such as peroxynitrite) in a rat model of ligature-induced periodontitis. Formation of 3-nitrotyrosine, the stable product formed from tyrosine reacting with nitric-oxide-derived nitrating species, was detected inthe gingivomucosal tissue. 3-Nitrotyrosine immunohistochemical analysis revealed a significant elevation in the number of immunopositive leukocytes, and higher immunoreactivity of the gingival ligaments and epithelium in theligated than in the contralateral (control) side. On both sides, several 3-nitrotyrosine-positive bands and, on the ligated side, a unique 52-kDa 3-nitrotyrosine-positive band were detected by Western blot. However, in the sterile gingivomucosal. tissue of rat pups, no 3-nitrotyrosine or inducible nitric oxide synthase immunoreactivity was found. Analysis of these data suggests that resident bacteria of the gingivomucosal tissue induce an increase in reactive nitrogen species, which is greatly enhanced by plaque formation in periodontitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:32:52