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Titolo:
Interstitial pneumonia in progressive systemic sclerosis: Serial high-resolution CT findings with functional correlation

Autore:

Kim, EA; Johkoh, T; Lee, KS; Ichikado, K; Koh, EM; Kim, TS; Kim, EY;

Indirizzi:: Sung Kyun Kwan Univ, Samsung Med Ctr, Dept Radiol, Kangnam Ku, Seoul 135710, South Korea Sung Kyun Kwan Univ Seoul South Korea 135710 , Seoul 135710, South Korea Sung Kyun Kwan Univ, Samsung Med Ctr, Dept Med, Div Rheumatol, Seoul 135710, South Korea Sung Kyun Kwan Univ Seoul South Korea 135710 , Seoul 135710, South Korea Osaka Univ, Sch Med, Dept Radiol, Osaka 553, Japan Osaka Univ Osaka Japan 553 Univ, Sch Med, Dept Radiol, Osaka 553, Japan Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 ept Internal Med 1, Kumamoto 860, Japan
Titolo Testata:: JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 757 - 763
SICI:: 0363-8715(200109/10)25:5<757:IPIPSS>2.0.ZU;2-9
Fonte:: ISI
Lingua:: ENG
Soggetto:: IDIOPATHIC PULMONARY FIBROSIS; COMPUTED-TOMOGRAPHY; FUNCTION TESTS; DISEASE; INVOLVEMENT; SCLERODERMA; ALVEOLITIS; SOCIETY;
Keywords:: lung; lung, diseases; lung, fibrosis; connective tissues, diseases; computed tomography;
Tipo documento:: Article
Natura:: Periodico
Settore Disciplinare:: Clinical Medicine; Life Sciences
Citazioni:: 23
Recensione:
Indirizzi per estratti:: Indirizzo: Lee, KS Sung Kyun Kwan Univ, Samsung Med Ctr, Dept Radiol, Kangnam Ku, 50 Ilwon Dong, Seoul 135710, South Korea Sung Kyun Kwan Univ 50 Ilwon Dong Seoul South Korea 135710 Korea



Citazione:: E.A. Kim et al., "Interstitial pneumonia in progressive systemic sclerosis: Serial high-resolution CT findings with functional correlation", J COMPUT AS, 25(5), 2001, pp. 757-763

Abstract

Purpose: The aim of our study was to assess the serial high-resolution CT findings and their correlation with the results of pulmonary function testsin patients with progressive systemic sclerosis (PSS) and interstitial pneumonia. Method: The study included 40 patients with symptoms or signs of PSS and interstitial pneumonia, who underwent serial high-resolution CT scans (mean follow-up period 39 months). Seventeen patients simultaneously had serial pulmonary function tests (mean follow-up period 40 months). On high-resolution CT, the pattern and extent of parenchymal abnormalities were retrospectively analyzed. Serial changes on high-resolution CT were correlated with the changes of pulmonary function tests. Results: On initial CT, areas of ground-glass opacity (mean +/- SD extent 17.7 +/- 12.3% in all patients), irregular linear opacity (4.4 +/- 4.4% in 36 patients), small nodules (3.9 +/- 12.5% in 28), consolidation (1.9 +/- 4.2% in 13), and honeycombing (1.9 +/- 3.8% in 12) were seen. The total disease extent (p = 0.042) and extents of ground-glass opacity (18.9 +/- 15.5%;p = 0.04) and honeycombing (5.0 +/- 7.2%; p = 0.002) increased significantly on follow-up CT. Both forced vital capacity (from 2.4 +/- 0.4 to 2.0 +/-0.4 L; p = 0.002) and forced expiratory volume in 1 s (from 2.0 +/- 0.4 to1.6 +/- 0.3 L; p = 0.013) decreased significantly on follow-up examination. The increase in the extent of honeycombing on CT correlated significantlywith the decrease in diffusing capacity for carbon monoxide (r = -0.411, p= 0,049). Conclusion: In patients with PSS and interstitial pneumonia. the overall extent of disease and extents of honeycombing and ground-glass opacity increase significantly on follow-up CT. Increase of honeycombing correlates wellwith decrease of diffusing capacity for carbon monoxide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:13:21