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Titolo:
Assessment of weight-based versus standard dosing of heparin in patients with unstable angina
Autore:
Folstad, J; Caron, MF; Nguyen, L; White, CM;
Indirizzi:
Hartford Hosp, Drug Informat Ctr, Hartford, CT 06102 USA Hartford Hosp Hartford CT USA 06102 Informat Ctr, Hartford, CT 06102 USA Univ Connecticut, Sch Pharm, Storrs, CT USA Univ Connecticut Storrs CT USA iv Connecticut, Sch Pharm, Storrs, CT USA Vet Adm Connecticut Hlth Care Syst, W Haven, CT USA Vet Adm Connecticut Hlth Care Syst W Haven CT USA Syst, W Haven, CT USA
Titolo Testata:
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
fascicolo: 4, volume: 26, anno: 2001,
pagine: 283 - 286
SICI:
0269-4727(200108)26:4<283:AOWVSD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; ACC/AHA GUIDELINES; MANAGEMENT; NOMOGRAM; ASPIRIN; TRIAL;
Keywords:
heparin; pharmacist; unstable angina; weight-based;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: White, CM Hartford Hosp, Drug Informat Ctr, Hartford, CT 06102 USA Hartford Hosp Hartford CT USA 06102 Ctr, Hartford, CT 06102 USA
Citazione:
J. Folstad et al., "Assessment of weight-based versus standard dosing of heparin in patients with unstable angina", J CLIN PH T, 26(4), 2001, pp. 283-286

Abstract

Objective; To assess whether a weight-based dosing regimen (80 u/kg + 18 u/kg/h) or a standard-fixed dose regimen (5000 u + 1000 u/h) of heparin is more appropriate in patients with unstable angina (UA). Method: A drug use evaluation was conducted. Patient data for all patientsweighing less than 100 kg who were in the coronary care unit of a VeteransAdministration Hospital and who received heparin for UA (>24 h) over a 7-month period were included. For the first 4 months, patients were given standard heparin dosing and in the final 3 months patients were given heparin based on weight. The proportion of patients achieving activated partial thromboplastin times (aPTTs) that were at least therapeutic during therapy, thetime to achieve the aPTT at a level that was at least therapeutic, and thenumber of patients with aPTTs over the therapeutic range were compared between groups. Results: Patients in the group receiving weight-based heparin therapy (n =23) were significantly more likely to achieve an aPTT that was at least therapeutic than patients receiving standard therapy (n = 42, 100% vs. 76%, respectively, P = 0.011). When all the patients in each group who achieved an aPTT that was at least therapeutic were compared, the weight-based group achieved the levels significantly faster than the standard-fixed dosing group (7.3 +/- 6.1 vs. 22.6 +/- 17.6 h, respectively, P = 0.0003). However, the use of weight-based dosing was associated with a higher incidence of achieving supertherapeutic aPTTs than standard therapy (78.3% vs. 50.0%, respectively, P = 0.049). Conclusion: Patients with UA may achieve therapeutic aPTTs faster than those on standard therapy but they also have a higher risk of achieving a supertherapeutic aPTT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:37:51