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Titolo:
Activation of interictal spiking in mesiotemporal lobe epilepsy by propofol-induced sleep
Autore:
Leijten, FSS; Teunissen, NW; Wieneke, GH; Knape, JTA; Schobben, AFAM; van Huffelen, AC;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Clin Neurophysiol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Rudolf Magnus Inst Neurosci, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Inst Anasthesiol, Div Perioperat Care Anesthesiol &Pain Med, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Pharmacotherapy, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands
Titolo Testata:
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
fascicolo: 3, volume: 18, anno: 2001,
pagine: 291 - 298
SICI:
0736-0258(200105)18:3<291:AOISIM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL LOBECTOMY; STATUS EPILEPTICUS; SEIZURE ORIGIN; LOCALIZATION; FOCI; EEG; DEPTH; RECORDINGS; ALFENTANIL; ANESTHESIA;
Keywords:
epilepsy; propofol; sedation; EEG; spikes; mesiotemporal lobe;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Leijten, FSS Univ Utrecht, Med Ctr, Dept Clin Neurophysiol, F02-230,POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht F02-230,POB 85500 Utrecht Netherlands NL-3508 GA
Citazione:
F.S.S. Leijten et al., "Activation of interictal spiking in mesiotemporal lobe epilepsy by propofol-induced sleep", J CL NEURPH, 18(3), 2001, pp. 291-298

Abstract

The objective of this study was to test whether low-dose propofol increases the number of interictal spikes in patients with mesiotemporal lobe epilepsy, and to determine whether Us is the result of intrinsic properties and is restricted to the primary epileptogenic focus. Controlled infusion of propofol in step-up/-down target concentrations of 0, 0.3, 0.6, and 0.8 mg/L was administered to 10 patients during a 3.5-hour daytime EEG registration. The number of spikes were counted and related to propofol concentration and sleep level. Results were compared with a spontaneous, nocturnal first sleep cycle in 9 of 10 patients. An patients entered nonrapid eye movement 1 sleep during propofol administration, and 8 reached nonrapid eye movement 2sleep. In 7 patients who showed spikes, spikes were related to sleep (P < 0.05) and not to increasing P = 0.1) or decreasing (P = 0.5) propofol concentration. Six of nine patients showed more spikes during spontaneous (nocturnal) sleep than during propofolinduced sleep. Contralateral spiking was not suppressed selectively. Low-dose propofol is a safe means of increasing spiking in these patients because it induces sleep. There were, no signs of an intrinsic epileptogenicity of propofol or a selective effect on ipsilateral spikes. Controlled sleep induction will increase the yield of interictal spikes during short interictal recordings such as in magnetoencephalography.

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Documento generato il 10/07/20 alle ore 09:42:11