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Titolo:
Hepatobiliary cholesterol transport as not impaired in Abca1-null mice lacking HDL
Autore:
Groen, AK; Bloks, VW; Bandsma, RHJ; Ottenhoff, R; Chimini, G; Kuipers, F;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Groningen Hosp, Dept Pediat, Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands ediat, Groningen, Netherlands CNRS, INSERM, Ctr Immunol, Marseille, France CNRS Marseille FranceCNRS, INSERM, Ctr Immunol, Marseille, France
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 6, volume: 108, anno: 2001,
pagine: 843 - 850
SICI:
0021-9738(200109)108:6<843:HCTANI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; ISOTOPOMER DISTRIBUTION ANALYSIS; BINDING CASSETTE TRANSPORTER-1; TANGIER-DISEASE PATIENTS; RECEPTOR SR-BI; NEWLY SYNTHESIZED CHOLESTEROL; APOLIPOPROTEIN-A-I; PLASMA-MEMBRANE; DEFICIENT MICE; APOPTOTIC CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Groen, AK Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, F0-222,Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam F0-222,Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
A.K. Groen et al., "Hepatobiliary cholesterol transport as not impaired in Abca1-null mice lacking HDL", J CLIN INV, 108(6), 2001, pp. 843-850

Abstract

The ABC transporter ABCA1 regulates HDL levels and is considered to control the first step of reverse cholesterol transport from the periphery to theliver. To test this concept, we studied the effect of ABCA1 deficiency on hepatic metabolism and hepatobiliary flux of cholesterol in mice. Hepatic lipid contents and biliary secretion rates were determined in Abca1(-/-), Abca1(+/-), and Abca1(+/+) mice with a DBA background that were fed either standard chow or a high-fat, high-cholesterol diet. Hepatic cholesterol and phospholipid contents in Abca1(-/-) mice were indistinguishable from those in Abca1(+/-) and Abca1(+/+) mice on both diets. In spite of the absence of HDL, biliary secretion rates of cholesterol, bile salts, and phospholipid were unimpaired in Abca1(-/-) mice. Neither the hepatic expression levels ofgenes controlling key steps in cholesterol metabolism nor the contributionof de novo synthesis to biliary cholesterol and bile salts were affected by Abca genotype. Finally, fecal excretion of neutral and acidic sterols wassimilar in all groups. We conclude that plasma HDL levels and ABCA1 activity do not control net cholesterol transport from the periphery via the liver into the bile, indicating that the importance of HDL in reverse cholesterol transport requires re-evaluation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:29:21