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Titolo:
Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma
Autore:
Tawab, MA; Kaunzinger, A; Bahr, U; Karas, M; Wurglics, M; Schubert-Zsilavecz, M;
Indirizzi:
Univ Frankfurt, Inst Pharmaceut Chem, D-60439 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60439 hem, D-60439 Frankfurt, Germany
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 2, volume: 761, anno: 2001,
pagine: 221 - 227
SICI:
1387-2273(20010925)761:2<221:DOAHLC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
VALIDATION; 5-LIPOXYGENASE;
Keywords:
11-keto-beta-boswellic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Bahr, U Univ Frankfurt, Inst Pharmaceut Chem, Marie Curie Str 9, D-60439 Frankfurt, Germany Univ Frankfurt Marie Curie Str 9 Frankfurt Germany D-60439 ermany
Citazione:
M.A. Tawab et al., "Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma", J CHROMAT B, 761(2), 2001, pp. 221-227

Abstract

A validated HPLC method for the determination of 11-keto-beta -boswellic acid (KBA) in human plasma was developed. The method involves the solid-phase extraction of KBA from plasma followed by a separation with reversed-phase HPLC. Calibration was based on external standardisation and ranged between 0.1 and 2.0 mug KBA per ml plasma. Linearity was established over the entire calibration range and in each case the coefficient of correlation (r(2)) was above 0.99. The recovery of KBA from plasma was 85.7%. It was furtherdemonstrated that the method can be applied successfully to monitor the level of KBA in plasma. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:14:28