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Titolo:
Effect of antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood
Autore:
Aynaci, FM; Orhan, F; Orem, A; Yildirmus, S; Gedik, Y;
Indirizzi:
Karadeniz Tech Univ, Dept Pediat Neurol, TR-61080 Trabzon, Turkey Karadeniz Tech Univ Trabzon Turkey TR-61080 ol, TR-61080 Trabzon, Turkey Karadeniz Tech Univ, Dept Pediat, TR-61080 Trabzon, Turkey Karadeniz Tech Univ Trabzon Turkey TR-61080 at, TR-61080 Trabzon, Turkey Karadeniz Tech Univ, Dept Biochem, TR-61080 Trabzon, Turkey Karadeniz TechUniv Trabzon Turkey TR-61080 em, TR-61080 Trabzon, Turkey
Titolo Testata:
JOURNAL OF CHILD NEUROLOGY
fascicolo: 5, volume: 16, anno: 2001,
pagine: 367 - 369
SICI:
0883-0738(200105)16:5<367:EOADOP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERM ANTICONVULSIVE TREATMENT; EPILEPTIC CHILDREN; SERUM-LIPIDS; TOTAL CHOLESTEROL; HDL CHOLESTEROL; CARBAMAZEPINE; EVOLUTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Aynaci, FM Karadeniz Tech Univ, Dept Pediat Neurol, TR-61080 Trabzon, Turkey Karadeniz Tech Univ Trabzon Turkey TR-61080 0 Trabzon, Turkey
Citazione:
F.M. Aynaci et al., "Effect of antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood", J CHILD NEU, 16(5), 2001, pp. 367-369

Abstract

Antiepileptic drugs may alter plasma lipid status in epileptic patients. We conducted a study to assess the effect of phenobarbital, carbamazepine, and valproate on plasma levels of lipoprotein (a), total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein A, and apolipoprotein B in 22 epileptic children. The children were separated as group 1, seven children, mean age 1.6 +/- 0.2years, treated with phenobarbital, 5 mg/kg/day, twice daily; group 2, seven children, mean age 9.8 +/- 1.2 years, treated with carbamazepine, 20 mg/kg/day, twice daily; and group 3, eight children, mean age 6.8 +/- 0.6 years, treated with valproate, 20 mg/kg/day, twice daily. Plasma lipoprotein (a)and other lipid levels were studied before (pretreatment) and at 3 and 6 months of treatment. Friedman two-way analysis of variance and Wilcoxon's signed-rank test were used for statistical analysis, and the results were expressed as the mean and standard error of the mean. The mean age of childrenin group 1 was significantly low, compared with groups 2 and, 3 (P < .001). The mean pretreatment lipid levels between the groups were not significant. The increase in lipoprotein (a) at 3 and 6 months and high-density lipoprotein cholesterol at 6 months was statistically significant in group 1 (P < .025). We suggest a careful monitoring of plasma levels of lipoprotein (a) and other lipids in epileptic children treated with antiepileptic drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:13:41