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Titolo:
Orally active insulin mimics: where do we stand now?
Autore:
Balasubramanyam, M; Mohan, V;
Indirizzi:
MDRF, Gopalapuram 600086, Chennai, India MDRF Gopalapuram Chennai India 600086 Gopalapuram 600086, Chennai, India
Titolo Testata:
JOURNAL OF BIOSCIENCES
fascicolo: 3, volume: 26, anno: 2001,
pagine: 383 - 390
SICI:
0250-5991(200109)26:3<383:OAIMWD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ADIPOSE-CELLS; PROTEIN-TYROSINE PHOSPHATASES; IRS-SIGNALING SYSTEM; RECEPTOR KINASE; SKELETAL-MUSCLE; OBESE SUBJECTS; STIMULATED TRANSLOCATION; PEROXOVANADIUM COMPOUNDS; POTENTIAL INVOLVEMENT; ANTIDIABETIC ACTIVITY;
Keywords:
insulin mimetic; insulin receptor tyrosine kinase; PI 3-kinase; vanadium;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Balasubramanyam, M MDRF, 35 Conran Smith Rd, Gopalapuram 600086, Chennai, India MDRF 35 Conran Smith Rd Gopalapuram Chennai India 600086
Citazione:
M. Balasubramanyam e V. Mohan, "Orally active insulin mimics: where do we stand now?", J BIOSCI, 26(3), 2001, pp. 383-390

Abstract

The war against diabetes through the development of new drugs is an ongoing continuous process to counter the alarming global increase in the prevalence of diabetes and its complications, particularly in developing countrieslike India. Unfortunately, the speed with which our knowledge of diabetes and its effects is expanding is not matched by the availability of new drugs. Following the identification of the insulin receptor (IR), its intrinsickinase activity and molecular cloning, many studies have looked at IR as an ideal drug target. This review summarizes in brief the latest advancements in this field with particular reference to the current situation in respect of the development of orally active insulin mimetics in the treatment oftype 2 diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:53:15