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Titolo:
A COMPARATIVE-STUDY OF AMLODIPINE AND VERAPAMIL IN HYPERTENSIVE PATIENTS UNDERGOING HEMODIALYSIS
Autore:
TIMIO M; VERDURA C; LOLLI S; LUPPARELLI A;
Indirizzi:
HOSP FOLIGNO,DEPT MED & NEPHROL,DEPT NEPHROL,VIA XX SETTEMBRE 22 I-06121 PERUGIA ITALY HOSP FOLIGNO,DEPT INTERNAL MED PERUGIA ITALY
Titolo Testata:
Clinical drug investigation
, volume: 13, anno: 1997, supplemento:, 1
pagine: 73 - 76
SICI:
1173-2563(1997)13:<73:ACOAAV>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M. Timio et al., "A COMPARATIVE-STUDY OF AMLODIPINE AND VERAPAMIL IN HYPERTENSIVE PATIENTS UNDERGOING HEMODIALYSIS", Clinical drug investigation, 13, 1997, pp. 73-76

Abstract

The aim of this study was to compare the antihypertensive effects of amlodipine and verapamil in uraemic patients undergoing chronic haemodialysis. After a 1-week drug washout phase, 40 patients (30 males, 10 females; mean age 57.18 +/- 13.4 years) were randomised to 12 weeks oftreatment with amlodipine 5 mg/day (21 patients) or verapamil 120 mg/day (19 patients). Dosages were doubled after 4 weeks if adequate blood pressure control (diastolic blood pressure less than or equal to 90 mm Hg) had not been achieved. Haemodialysis was performed 3 times a week for a total of 12 hours. After 4 weeks of treatment, mean systolic and diastolic blood pressures were significantly lower (p < 0.001) than baseline values in both groups. On treatment completion (week 12), the final reduction in systolic/diastolic blood pressure in the amlodipine group was 21/23 mm Hg, and in the verapamil group it was 17/21 mm Hg. Normal values (diastolic blood pressure < 90 mm Hg) were reached in 81% and 74% of the amlodipine and verapamil groups, respectively. Heart rates remained unchanged in patients treated with amlodipine, but those receiving the higher dosage of verapamil experienced significantincreases during the latter part of the study. The incidence of adverse events was low with both drugs and similar to that seen in nonuraemic hypertensive patients. Thus, the results of this study su st that amlodipine is a well tolerated and effective treatment for arterial hypertension in patients with renal failure undergoing haemodialysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:54:46