Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhibition of p53 transcriptional activity by the S100B calcium-binding protein
Autore:
Lin, J; Blake, M; Tang, C; Zimmer, D; Rustandi, RR; Weber, DJ; Carrier, F;
Indirizzi:
Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 & Mol Biol, Baltimore, MD 21201 USA Univ S Alabama, Dept Pharmacol, Mobile, AL 36688 USA Univ S Alabama Mobile AL USA 36688 , Dept Pharmacol, Mobile, AL 36688 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 37, volume: 276, anno: 2001,
pagine: 35037 - 35041
SICI:
0021-9258(20010914)276:37<35037:IOPTAB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-LINES; DNA-BINDING; GROWTH; DOMAIN; GENE; S100B(BETA-BETA); IDENTIFICATION; EXPRESSION; PATHWAY; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Carrier, F Univ Maryland, Sch Med, Dept Biochem & Mol Biol, 108 N Greene St,Rm 330, Baltimore, MD 21201 USA Univ Maryland 108 N Greene St,Rm 330 Baltimore MD USA 21201 USA
Citazione:
J. Lin et al., "Inhibition of p53 transcriptional activity by the S100B calcium-binding protein", J BIOL CHEM, 276(37), 2001, pp. 35037-35041

Abstract

The levels of S100 Ca2+-binding proteins correlate with the progression ofcertain tumors, but their role, if any, in carcinogenesis is still poorly understood. S100B protein associates with both the p53 oligomerization domain (residues 325-355) and the extreme C terminus of the tumor suppressor p53 (residues 367-392). Consequently, S100B inhibits p53 tetramer formation and p53 phosphorylation mediated by protein kinase C, on p53 C-terminal end. In this report, we show that the S100B protein decreases p53 DNA binding and transcriptional activity. The effect of S100B is reflected in vivo by a reduced accumulation of p53, p21, and MDM2 protein levels in co-transfection assays and in response to bleomycin. The S100B can still interact with p53 in the absence of p53 extreme C-terminal end and reduce the expression ofp53 downstream effector genes. These data indicate that S100B does not require p53 extreme C-terminal end to inhibit p53 activity. Collectively, these findings imply that elevated levels of S100B in tumors such as astrocytomas and gliomas could inhibit p53 functions and contribute to cancer progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:32:57