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Titolo:
Enhancement of oxidative damage to cultured cells and Caenorhabditis elegans by mitochondrial electron transport inhibitors
Autore:
Ishiguro, H; Yasuda, K; Ishii, N; Ihara, K; Ohkubo, T; Hiyoshi, M; Ono, K; Senoo-Matsuda, N; Shinohara, O; Yosshii, F; Murakami, M; Hartman, PS; Tsuda, M;
Indirizzi:
Tokai Univ, Sch Med, Dept Mol Life Sci, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 Mol Life Sci, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Pediat, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 , Dept Pediat, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Neurol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 , Dept Neurol, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Obstet & Gynecol, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 tet & Gynecol, Kanagawa 2591193, Japan Texas Christian Univ, Dept Biol, Ft Worth, TX 76129 USA Texas Christian Univ Ft Worth TX USA 76129 t Biol, Ft Worth, TX 76129 USA
Titolo Testata:
IUBMB LIFE
fascicolo: 4, volume: 51, anno: 2001,
pagine: 263 - 268
SICI:
1521-6543(200104)51:4<263:EOODTC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-MITOCHONDRIA; HYDROGEN-PEROXIDE; COMPLEX-III; NEMATODE; DEHYDROGENASE; GENERATION; CERAMIDE; STRESS;
Keywords:
C elegans; electron transport inhibitors; mitochondria; oxidative stress; PC 12 cells; primary hepatocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuda, M Tokai Univ, Sch Med, Dept Mol Life Sci, Kanagawa 2591193, Japan Tokai Univ Kanagawa Japan 2591193 Sci, Kanagawa 2591193, Japan
Citazione:
H. Ishiguro et al., "Enhancement of oxidative damage to cultured cells and Caenorhabditis elegans by mitochondrial electron transport inhibitors", IUBMB LIFE, 51(4), 2001, pp. 263-268

Abstract

The mechanisms that lead to mitochondrial damage under oxidative stress conditions were examined in primary and cultured cells as well as in the nematode Caenorhabditis elegans (C elegans) treated simultaneously with electron transport inhibitors and oxygen gas. Oxygen loading enhanced the damage of PC 12 cells by thenoyltrifluoroacetone (TTFA, a complex II inhibitor), but did not by rotenone (a complex I inhibitor), antimycin (a complex III inhibitor), and sodium azide (a complex IV inhibitor). In primary hepatocytes,the enhancement was observed with the addition of sodium azide and rotenone, but not by TTFA or antimycin. In the nematode, only rotenone and TTFA enhanced the sensitivity under hyperoxia. These results demonstrate that highly specific inhibitors of electron transport can induce oxygen hypersensitivity in cell levels such as PC 12 cells and primary hepatocytes, and animallevel of C. elegans. In addition the cell damage is different dependent oncell type and organism.

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Documento generato il 01/04/20 alle ore 19:25:56