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Titolo:
Evolutionary aspects of calmodulin
Autore:
Friedberg, F; Rhoads, AR;
Indirizzi:
Howard Univ, Coll Med, Dept Biochem & Mol Biol, Washington, DC 20059 USA Howard Univ Washington DC USA 20059 & Mol Biol, Washington, DC 20059 USA
Titolo Testata:
IUBMB LIFE
fascicolo: 4, volume: 51, anno: 2001,
pagine: 215 - 221
SICI:
1521-6543(200104)51:4<215:EAOC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNAS; RAT CALMODULIN; BINDING PROTEIN; TRANSGENIC MICE; LEADER SEGMENT; GENE-II; EXPRESSION; AMPHETAMINE; SEQUENCES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Friedberg, F Howard Univ, Coll Med, Dept Biochem & Mol Biol, 520 W St NW, Washington, DC 20059 USA Howard Univ 520 W St NW Washington DC USA 20059 DC 20059 USA
Citazione:
F. Friedberg e A.R. Rhoads, "Evolutionary aspects of calmodulin", IUBMB LIFE, 51(4), 2001, pp. 215-221

Abstract

Calmodulin (CaM) is a major cellular sensor of calcium signaling, interacts with numerous proteins associated with cellular second messenger systems (e.g., cyclic AMP, nitric oxide), and is associated with neurosecretory activity. An identical CaM protein consisting of four helix-loop-helix regionsthat arose by gene duplication is encoded by three nonallelic mammalian genes that are some of the most highly conserved genes known. Differential tissue and cellular expression of each CaM suggest unique functions that promote strong selective preservation of these replicate, yet distinct, CaM genes in mammals. Each gene displays the same exon-intron arrangement but is characterized by distinct promoter elements and by unique 5'- and 3'-untranslated regions that are highly conserved among human, rat, and mouse. These distinct untranslated regions may permit regulation of CaM levels at discrete cellular sites during differentiation and in highly specialized cell types such as neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:57:28