Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Photodynamic therapy: Palliative and curative aspects
Autore:
Haussinger, K; Diaz-Jimenez, JP; Rodriguez, AN; Stanzel, F; Huber, RM; Pichler, J; Baumgartner, R;
Indirizzi:
Asklepios Fachkliniken Munchen Gauting, Zentrum Pneumol & Thoraxchirurg, D-82131 Gauting, Germany Asklepios Fachkliniken Munchen Gauting Gauting Germany D-82131 , Germany Bellvitge Univ Hosp, Endoscopy & Laser Unit, Barcelona, Spain Bellvitge Univ Hosp Barcelona Spain copy & Laser Unit, Barcelona, Spain Asklepios Fachkliniken Munchen Gauting, Clin Pneumol & Thorac Surg, Gauting, Germany Asklepios Fachkliniken Munchen Gauting Gauting Germany Gauting, Germany LMU, Klinikum Innenstadt, Med Klin, Munich, Germany LMU Munich GermanyLMU, Klinikum Innenstadt, Med Klin, Munich, Germany Univ Munich, Dept Urol, Laser Res Inst, Munich, Germany Univ Munich Munich Germany , Dept Urol, Laser Res Inst, Munich, Germany
Titolo Testata:
INTERVENTIONAL BRONCHOSCOPY
, volume: 30, anno: 2000,
pagine: 159 - 170
SICI:
1422-2140(2000)30:<159:PTPACA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL LUNG-CANCER; CLINICAL STAGE-I; RADIATION-THERAPY; BRONCHOGENIC-CARCINOMA; DISEASE; TUMORS; PHOTORADIATION; RADIOTHERAPY; EXPERIENCE; MANAGEMENT;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Haussinger, K Asklepios Fachkliniken Munchen Gauting, Zentrum Pneumol & Thoraxchirurg, Robert Koch Allee 2, D-82131 Gauting, Germany Asklepios Fachkliniken Munchen Gauting Robert Koch Allee 2 Gauting Germany D-82131
Citazione:
K. Haussinger et al., "Photodynamic therapy: Palliative and curative aspects", PROG R RES, 30, 2000, pp. 159-170

Abstract

Photodynamic therapy (PDT) is based on the interaction of tumor-selective photosensitizers and laser light. This interaction causes selective death of tumor cells. For palliative intention, PDT in comparison to Nd:YAG laser is approximately equally effective in relieving endobronchial obstruction by tumor. The time to treatment failure is slightly longer after PDT than after Nd:YAG laser resection, and the risk of reobstruction after PDT is lower than after Nd:YAG therapy. Additionally, PDT in most cases can be performed with flexible bronchoscopes and local anesthesia because there is no discomfort or significant risk during intervention. Compared to Nd:YAG laser recanalization PDT, however, has no immediate effect and therefore is not suitable for treatment of acute respiratory failure. For centrally located early lung cancers, treatment of incurative intention, the histologically confirmed complete remission rate 3 weeks after PDT is about 90%. However, over a long-term, only 50-70% of the patients remain stable. Therefore, PDT with curative intention does not achieve the success rates of surgical treatment with more than 80% and should be performed only in inoperable or high-risk patients. A main disadvantage of PDT is a prolonged photosensitization of skin and eyes. Strict protection from the sun is essential to avoid severe reactions. For patients, treated with palliative intention, with a mean survival of only 2-3 months, this means a severe reduction of quality of life. For patients with early-stage cancers treated with curative intention, the photosensitization of skin is less important in relation to the long mean survival time of these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:11:15