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Titolo:
Endoluminal brachytherapy in central lung cancer
Autore:
Fischer, R; Huber, RM;
Indirizzi:
Univ Munich, Klinikum Innenstadt, Dept Med, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 dt, Dept Med, D-80336 Munich, Germany
Titolo Testata:
INTERVENTIONAL BRONCHOSCOPY
, volume: 30, anno: 2000,
pagine: 146 - 158
SICI:
1422-2140(2000)30:<146:EBICLC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-RATE BRACHYTHERAPY; REMOTE AFTERLOADING BRACHYTHERAPY; RATE ENDOBRONCHIAL BRACHYTHERAPY; RATE INTRALUMINAL RADIOTHERAPY; EXTERNAL-BEAM RADIOTHERAPY; BRONCHOGENIC-CARCINOMA; RADIATION-THERAPY; AIRWAY OCCLUSION; LOCAL-CONTROL; IRRADIATION;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Fischer, R Univ Munich, Klinikum Innenstadt, Dept Med, Ziemssenstr 1, D-80336 Munich,Germany Univ Munich Ziemssenstr 1 Munich Germany D-80336 unich,Germany
Citazione:
R. Fischer e R.M. Huber, "Endoluminal brachytherapy in central lung cancer", PROG R RES, 30, 2000, pp. 146-158

Abstract

Brachytherapy means the direct placement of a highly radioactive source inside a tumor mass. This can be done either by implanting the source directly into the tumor, via the natural route (endoluminal brachytherapy) or by placing the source into the tumor bed during tumor resection. Endoluminal brachytherapy employing the afterloading technique with iridium-192 high doserate (HDR) is largely applied for the curative and palliative treatment ofendobronchial tumors due to its tumor-specific and long-lasting effect. Endoluminal brachytherapy using flexible bronchoscopy and an HDR regimen can be performed on an outpatient basis and is not more strenuous for the patient than a diagnostic bronchoscopy. Symptomatic improvement can be achieved in 70-80% of patients, and sometimes small tumors can even be cured. The afterloading procedure can be combined with all other modalities of tumor therapy. It can be used as 'boost' to conventional external irradiation and aslocal treatment modality in patients on systemic chemotherapy or as the only local treatment. HDR treatment is usually delivered with 1-6 fractions at an interval of 1-3 weeks and a dose of 3-20 Gy per fraction (at 1 cm fromthe source axis). In patients previously treated with external beam radiation therapy and in the palliative setting, a regimen of 7-10 Gy (HDR) per fraction and a total of 2-3 fractions per treatment is recommended. However,the optimal dosage and fractionation schemes for the tumor therapy are still unknown and there is need for further studies. In about 10% of the patients, radiation bronchitis occurs, and there may be fatal hemorrhage, possibly related to the therapy. Overall, endobronchial brachytherapy is a well-tolerated, not very aggressive treatment option, especially in patients withreduced performance status.

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Documento generato il 02/04/20 alle ore 19:22:47