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Titolo:
Relating radiation-induced regional lung injury to changes in pulmonary function tests
Autore:
Fan, M; Marks, LB; Lind, P; Hollis, D; Woel, RT; Bentel, GG; Anscher, MS; Shafman, TD; Coleman, RE; Jaszczak, RJ; Munley, MT;
Indirizzi:
Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 tr, Dept Radiat Oncol, Durham, NC 27710 USA Duke Univ, Med Ctr, Canc Ctr Biostat, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Ctr, Canc Ctr Biostat, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Radiol, Durham, NC 27710 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 2, volume: 51, anno: 2001,
pagine: 311 - 317
SICI:
0360-3016(20011001)51:2<311:RRRLIT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
END-POINTS; PERFUSION; CANCER; IRRADIATION; PREDICTION; CARCINOMA; RADIOTHERAPY; RESECTION; SCANS; RISK;
Keywords:
radiation lung injury; pulmonary function tests; lung perfusion; single photon emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Marks, LB Duke Univ, Med Ctr, Dept Radiat Oncol, Box 3085, Durham, NC 27710 USA Duke Univ Box 3085 Durham NC USA 27710 085, Durham, NC 27710 USA
Citazione:
M. Fan et al., "Relating radiation-induced regional lung injury to changes in pulmonary function tests", INT J RAD O, 51(2), 2001, pp. 311-317

Abstract

Purpose: To determine whether the sum of radiotherapy (RT)-induced reductions in regional lung perfusion is quantitatively related to changes in global lung function as assessed by reductions in pulmonary function tests (PFTs). Methods and Materials: Two hundred seven patients (70% with lung cancer) who received incidental partial lung irradiation underwent PFTs (forced expiratory volume in 1 s and diffusion capacity for carbon monoxide) before andrepeatedly after RT as part of a prospective clinical study. Regional lungfunction was serially assessed before and after RT by single photon emission computed tomography perfusion scans. Of these, 53 patients had 105 post-RT evaluations of changes in both regional perfusion and PFTs, were withoutevidence of intrathoracic disease recurrence that might influence regionalperfusion and PITT findings, and were not taking steroids. The summation of the regional functional perfusion changes were compared with changes in PFTs using linear regression analysis. Results: Follow-up ranged from 3 to 86 months (median 19). Overall, a significant correlation was found between the sum of changes in regional perfusion and the changes in the PFTs (p = 0.002-0.24, depending on the particular PFT index). However, the correlation coefficients were small (r = 0.16-0.41). Conclusions: A statistically significant correlation was found between RT-induced changes in regional function (fe., perfusion) and global function (i.e., PFTs). However, the correlation coefficients are low, making it difficult to relate changes in perfusion to changes in the PFT results. Thus, with our current techniques, the prediction of changes in perfusion alone does not appear to be sufficient to predict the changes in PFTs accurately. Additional studies to clarify the relationship between regional and global lung injury are needed. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:11:00