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Titolo:
DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue
Autore:
Steinhart, H; Bohlender, J; Iro, H; Jung, V; Constantinidis, J; Gebhart, E; Pahl, S; Urbschat, S;
Indirizzi:
Univ Erlangen Nurnberg, ENT Dept, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univ Saarland, Inst Human Genet, D-66421 Homburg, Germany Univ Saarland Homburg Germany D-66421 an Genet, D-66421 Homburg, Germany Univ Saarland, Inst Pathol, D-66421 Homburg, Germany Univ Saarland Homburg Germany D-66421 t Pathol, D-66421 Homburg, Germany Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 4, volume: 19, anno: 2001,
pagine: 851 - 855
SICI:
1019-6439(200110)19:4<851:DAOC7I>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; ANALYSIS DETECTS FREQUENT; COPY NUMBER; SOLID TUMORS; HEAD; NECK; IMBALANCES; METASTASIS; SEQUENCES; PATTERNS;
Keywords:
squamous cell carcinoma; head and neck; tongue; comparative genomic hybridization; 7q;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Steinhart, H Univ Erlangen Nurnberg, ENT Dept, Waldstr 1, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Waldstr 1 Erlangen Germany D-91054 ny
Citazione:
H. Steinhart et al., "DNA amplification on chromosome 7q in squamous cell carcinoma of the tongue", INT J ONCOL, 19(4), 2001, pp. 851-855

Abstract

Squamous cell carcinoma of the head and neck exhibit a highly variable picture of chromosomal aberrations. In the present study the clearly defined anatomical region of the tongue was analyzed for potentially specific patterns of chromosomal alterations. Fresh tumor samples from 18 patients afflicted by squamous cell carcinoma of the tongue constituted the clinical basis of the present investigation. The tumor samples were analyzed on the basis of comparative genomic hybridization (CGH), a molecular cytogenetic FISH-approach. Gains in DNA copy numbers were detected as the predominant imbalance on chromosomes 7q (9/18), 3q (48/18), 16p (7/18) and 20q (7/18). The regions of minimal overlap on these chromosomes were mapped to 7q11.2q11.3 and 3q26. A conspicuous finding was the frequent detection of amplifications inthe 7q11 region. Gains in the 7q region have been rarely reported in CGH studies of tumors derived from different regions of the head and neck. Amplifications on 7q could thus be specifically linked with the tongue region and could correlate with specific clinical factors of this tumor entity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:48:38