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Titolo:
Enhanced GM3 expression, associated with decreased invasiveness, is induced by brefeldin A in bladder cancer cells
Autore:
Satoh, M; Ito, A; Nojiri, H; Handa, K; Numahata, K; Ohyama, C; Saito, S; Hoshi, S; Hakomori, SI;
Indirizzi:
Tohoku Univ, Sch Med, Dept Urol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Teikyo Univ, Fac Pharmaceut Sci, Sagamiko, Kanagawa 19901, Japan Teikyo Univ Sagamiko Kanagawa Japan 19901 Sagamiko, Kanagawa 19901, Japan Univ Washington, Pacific NW Res Inst, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 c NW Res Inst, Seattle, WA 98195 USA Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pathobiol, Seattle, WA 98195 USA Univ Washington, Dept Microbiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Microbiol, Seattle, WA 98195 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 4, volume: 19, anno: 2001,
pagine: 723 - 731
SICI:
1019-6439(200110)19:4<723:EGEAWD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY; COLORECTAL-CARCINOMA; SERIES GANGLIOSIDES; GLOBO-SERIES; ANTIGEN; INHIBITION; ADHESION; GLYCOSYLATION; MOTILITY; GALACTOSYLGLOBOSIDE;
Keywords:
brefeldin A; GM3; bladder cancer cells; CD9;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Satoh, M Tohoku Univ, Sch Med, Dept Urol, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 4, Japan
Citazione:
M. Satoh et al., "Enhanced GM3 expression, associated with decreased invasiveness, is induced by brefeldin A in bladder cancer cells", INT J ONCOL, 19(4), 2001, pp. 723-731

Abstract

We reported previously that non-invasive bladder cancer expresses high level of GM3 ganglioside, whereas invasive tumors have low levels. Since glycosphingolipid synthesis in Golgi is modified greatly by a macrocyclic lactone isolated from fungi, brefeldin A (BFA), we studied effects of BFA on expression of glycosphingolipids and on invasiveness of bladder cancer cell lines. Only GM3 synthesis in invasive tumors was greatly enhanced upon treatment with BFA; synthesis of other glycosphingolipids with lacto-series type 2or globo-series structure in both invasive and noninvasive tumors was not changed. Invasiveness of bladder cancer cells was greatly decreased in association with the great increase of GM3 synthesis induced by BFA treatment. Level of sialyl-Le(2), expressed in invasive cell line YTS1, which providesthe adhesive property of the cells to E-selectin, was unchanged upon BFA treatment. All the bladder cancer cell lines, regardless of invasiveness, highly express tetraspanin CD9. GM3 has been implicated as a co-factor of CD9in control of tumor cell motility. Down-regulation of CD9 is associated with metastatic properties of tumor cells and survival of patients with colonic cancer. Therefore, enhanced synthesis of GM3 induced by BFA, causing decrease of invasiveness in bladder cancer, is ascribable to the capability ofGM3 to interconnect integrin with CD9, in analogy to colonic cancer and perhaps many other types of cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:38:54