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Titolo:
Accumulation of p53 in esophageal squamous cell carcinoma
Autore:
Chino, O; Kijima, H; Shimada, H; Nishi, T; Tanaka, H; Kise, Y; Kenmochi, T; Himeno, S; Machimura, T; Tanaka, M; Inokuchi, S; Tajima, T; Osamura, RY; Makuuchi, H;
Indirizzi:
Tokai Univ, Sch Med, Dept Pathol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Surg, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Crit Care & Emergency Med, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 4, volume: 8, anno: 2001,
pagine: 359 - 363
SICI:
1107-3756(200110)8:4<359:AOPIES>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL-CANCER; SUPPRESSOR GENE; EXPRESSION; MUTATIONS; THROMBOSPONDIN-1; ADENOCARCINOMA; CARCINOGENESIS; P53-PROTEIN; PROGRESSION; PROGNOSIS;
Keywords:
esophagus; squamous cell carcinoma; p53 expression; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kijima, H Tokai Univ, Sch Med, Dept Pathol, Bohseidai, Isehara, Kanagawa 2591193, Japan Tokai Univ Bohseidai Isehara Kanagawa Japan 2591193 91193, Japan
Citazione:
O. Chino et al., "Accumulation of p53 in esophageal squamous cell carcinoma", INT J MOL M, 8(4), 2001, pp. 359-363

Abstract

p53 is one of the most important tumor suppressor genes. Mutation of the p53 gene can be detected immunohistochemically as over-expression of its protein in the nucleus. The p53 gene product is known to regulate cell growth and proliferation. Genetic alterations related to the carcinogenesis or progression of esophageal cancer are poorly understood. We examined accumulation of p53 protein in esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. p53 immunoreactivityin the cancer tissues was found in 61 (79.2%) of 77 esophageal squamous cell carcinomas. Over-expression of p53 protein (diffusely and focally positive staining) was seen in 70.1% (54/77). p53 over-expression was detected not only in the cases of in situ or intramucosal carcinomas, but also in invasive carcinomas. No significant correlations were found between p53 over-expression and clinicopathological features such as depth of tumor invasion, lymph node metastasis or venous/lymphatic invasion. These results suggestedthat p53 mutations may be closely associated with the early-stage of pre-invasive esophageal carcinoma, and p53 gene mutations may play an important role in the carcinogenesis of human esophageal cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:38:03