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Titolo:
beta-catenin expression as a prognostic indicator in cervical adenocarcinoma
Autore:
Imura, J; Ichikawa, K; Takeda, J; Fujimori, T;
Indirizzi:
Dokkyo Univ, Sch Med, Dept Surg, Mibu, Tochigi 3210293, Japan Dokkyo UnivMibu Tochigi Japan 3210293 Surg, Mibu, Tochigi 3210293, Japan Dokkyo Univ, Sch Med, Dept Mol Pathol, Shimotsuga, Tochigi, Japan Dokkyo Univ Shimotsuga Tochigi Japan Pathol, Shimotsuga, Tochigi, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 4, volume: 8, anno: 2001,
pagine: 353 - 358
SICI:
1107-3756(200110)8:4<353:BEAAPI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
UTERINE CERVIX; ALPHA-CATENIN; COLORECTAL-CANCER; E-CADHERIN; CLINICAL-SIGNIFICANCE; GASTRIC-CANCER; SURVIVAL; CELL; CARCINOMA; TUMORS;
Keywords:
cervical adenocarcinoma; uterus; beta-catenin; immunohistochemistry; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Imura, J Dokkyo Univ, Sch Med, Dept Surg, 880 Kitakobayashi,Shimotsuga, Mibu, Tochigi 3210293, Japan Dokkyo Univ 880 Kitakobayashi,Shimotsuga Mibu Tochigi Japan 3210293
Citazione:
J. Imura et al., "beta-catenin expression as a prognostic indicator in cervical adenocarcinoma", INT J MOL M, 8(4), 2001, pp. 353-358

Abstract

The purpose of this study was to assess the prognostic influence of beta -catenin expression by immuno-histochemistry in patients with cervical adenocarcinomas. The study group comprised of 51 patients who underwent total hysterectomy for cervical cancer. The median follow-up was 39 months (range 1-138 months). beta -catenin was expressed strongly on the membranes of normal cervical epithelial and glandular cells. Uniform membranous Bcatenin staining localized to intercellular borders was observed in 35% of tumors, whereas 65% of tumors demonstrated an abnormal pattern of reduced or aberrant beta -catenin expression (i.e., cytoplasmic and/or nuclear staining patterns). Abnormal beta -catenin immunoreactivity was associated statistically with advanced pathologic stage (p=0.018). The 10-year disease-free survival was 51.0% in patients with preserved expression of beta -catenin. On the other hand, a poorer prognosis was noted in the group with abnormal expressionof beta -catenin with a 10-year disease-free survival of 43.4%. By multivariate analysis, low pathologic stage (stages I and II, p=0.001) and preservation of beta -catenin expression (p=0.012) were independently favorable prognostic factors. Our results indicate that changes in beta -catenin expression occur during the progression of cervical adenocarcinoma to an invasivephenotype. These results suggest that beta -catenin is an important intercellular adhesion molecule. Assessment of beta -catenin immunoreactivity maybe a useful prognostic tool in cervical adenocarcinoma complementary to established prognostic factors. Furthermore, we developed a strategy for choosing biomarkers representing the steps in malignant progression in an effort to identify patients with occult metastases who will need adjuvant therapy and spare women from unnecessary interventions.

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Documento generato il 31/03/20 alle ore 03:28:54