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Titolo:
Low-dose dexamethasone augments the ovarian response to exogenous gonadotrophins leading to a reduction in cycle cancellation rate in a standard IVF programme
Autore:
Keay, SD; Lenton, EA; Cooke, ID; Hull, MGR; Jenkins, JM;
Indirizzi:
Univ Warwick, Sch Biol Sci, Coventry CV4 7AL, W Midlands, England Univ Warwick Coventry W Midlands England CV4 7AL 7AL, W Midlands, England Univ Sheffield, Jessop Hosp Women, Dept Obstet & Gynaecol, Sheffield S3 7RE, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S3 7RE S Yorkshire, England Univ Bristol, St Michaels Hosp, Div Obstet & Gynaecol, Bristol BS2 8EG, Avon, England Univ Bristol Bristol Avon England BS2 8EG Bristol BS2 8EG, Avon, England
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 9, volume: 16, anno: 2001,
pagine: 1861 - 1865
SICI:
0268-1161(200109)16:9<1861:LDATOR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; GROWTH-FACTOR-BINDING; HUMAN GRANULOSA-CELLS; INVITRO FERTILIZATION; EMBRYO-TRANSFER; POOR RESPONDERS; STIMULATION; HORMONE; HYPERSTIMULATION; PREDNISOLONE;
Keywords:
dexamethasone co-treatment; gonadotrophins; IVF; ovarian stimulation; poor response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Keay, SD Univ Warwick, Sch Biol Sci, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England Univ Warwick Gibbet Hill Rd Coventry W Midlands England CV4 7AL d
Citazione:
S.D. Keay et al., "Low-dose dexamethasone augments the ovarian response to exogenous gonadotrophins leading to a reduction in cycle cancellation rate in a standard IVF programme", HUM REPR, 16(9), 2001, pp. 1861-1865

Abstract

BACKGROUND: Cancellation of assisted conception cycles because of poor ovarian response to gonadotrophins is a significant problem in assisted reproduction. Various adjuvant treatments have been suggested to improve responsiveness. This study reports on the potential benefits of low dose dexamethasone. METHODS: Patients <40 years of age were invited to participate in a twin centre prospective double blind randomized placebo controlled study. A total of 290 patients were recruited and computer randomized using sealed envelopes to receive either I mg dexamethasone (n = 145) or placebo tablets (n = 145) in addition to a standard long protocol gonadotrophin-releasing hormone analogue with gonadotrophin stimulation regime. RESULTS: A significantly lower cancellation rate for poor ovarian response was observed in the dexamethasone group compared with controls (2.8 versus 12.4% respectively, P< 0.002). Further comparisons between the dexamethasone group and controlswere made of median fertilization rates (60 versus 61% respectively, NS), implantation rates (16.3 versus 11.6% respectively, NS) and pregnancy rate per cycle started (26.9 versus 17.2%, NS). The benefit was apparent in patients both with polycystic and normal ovaries. CONCLUSION: Low dose dexamethasone co-treatment reduces the incidence of poor ovarian response. It may increase clinical pregnancy rates and should be considered for inclusion in stimulation regimes to optimize ovarian response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:52:04