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Titolo:
Baseline non-fasting serum leptin concentration to body mass index ratio is predictive of IVF outcomes
Autore:
Brannian, JD; Schmidt, SM; Kreger, DO; Hansen, KA;
Indirizzi:
Univ S Dakota, Hlth Sci Ctr, Sch Med, Dept Obstet & Gynecol, Sioux Falls, SD 57105 USA Univ S Dakota Sioux Falls SD USA 57105 Gynecol, Sioux Falls, SD 57105 USA
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 9, volume: 16, anno: 2001,
pagine: 1819 - 1826
SICI:
0268-1161(200109)16:9<1819:BNSLCT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICULAR-FLUID LEPTIN; OBESE GENE-PRODUCT; GRANULOSA-CELLS; PLASMA LEPTIN; GROWTH-FACTOR; INSULIN; WOMEN; EXPRESSION; REPRODUCTION; ENDOMETRIUM;
Keywords:
body mass index; IVF outcome; leptin; predictive factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Brannian, JD Univ S Dakota, Hlth Sci Ctr, Sch Med, Dept Obstet & Gynecol, 1400 W 22nd St, Sioux Falls, SD 57105 USA Univ S Dakota 1400 W 22nd St Sioux Falls SD USA 57105 105 USA
Citazione:
J.D. Brannian et al., "Baseline non-fasting serum leptin concentration to body mass index ratio is predictive of IVF outcomes", HUM REPR, 16(9), 2001, pp. 1819-1826

Abstract

BACKGROUND: The present study was designed to determine whether circulating leptin concentrations and/ or body mass index (BMI) in women undergoing IVF are predictive of outcomes. METHODS: IVF cycle outcomes, e.g. fertilization, embryo development, implantation, pregnancy, were analysed relative tobaseline (i.e. day gonadotrophin stimulation was initiated) non-fasting serum leptin concentrations and BMI. RESULTS: Serum leptin concentrations correlated with BMI (r = 0.739, P < 0.0001) as expected. Multiple logistic regression analyses showed correlation between serum leptin and pregnancy success (likelihood ratio = 5.198, P < 0.05), but there was no association between pregnancy and BMI. However, the serum leptin to BMI ratio was more strongly correlated (likelihood ratio = 7.258, P < 0.01) with pregnancy successthan was leptin alone. Moreover, women with a low leptin:BMI ratio (<less than or equal to>0.3) had significantly more superior quality embryos on day 3 post-retrieval (2.5 versus 1.4, P < 0.05, Kruskal-Wallis) and a greaterimplantation rate (26.7 versus 13.2%, P < 0.025, chi (2)) than women with a high leptin:BMI ratio (greater than or equal to0.7). CONCLUSIONS: The leptin:BMI ratio appears to be highly predictive of IVF success. Elevated leptin concentrations, particularly relative to BMI, may negatively impact fertility by assisted reproduction, possibly through direct ovarian actions resulting in impaired oocyte quality and/or early embryo development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:58:25