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Titolo:
Dexamethasone attenuates neutrophil infiltration in the rat kidney in ischemia/reperfusion injury: The possible role of nitroxyl
Autore:
Takahira, R; Yonemura, K; Fujise, Y; Hishida, A;
Indirizzi:
Hamamatsu Univ, Sch Med, Hemodialysis Unit, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Med 1, Hamamatsu, Shizuoka, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan ed 1, Hamamatsu, Shizuoka, Japan Hamamatsu Univ, Sch Med, Dept Chem, Hamamatsu, Shizuoka, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan Chem, Hamamatsu, Shizuoka, Japan
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 6, volume: 31, anno: 2001,
pagine: 809 - 815
SICI:
0891-5849(20010915)31:6<809:DANIIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; ACUTE-RENAL-FAILURE; INTERCELLULAR-ADHESION MOLECULE-1; ISCHEMIA-REPERFUSION INJURY; ENDOTHELIAL-CELLS; SUPEROXIDE-DISMUTASE; NO SYNTHASE; L-ARGININE; ICAM-1; EXPRESSION;
Keywords:
acute renal failure; adhesion molecule; dexamethasone; neutrophil; nitric oxide; free radicals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Yonemura, K Hamamatsu Univ, Sch Med, Hemodialysis Unit, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ 1-20-1 Handayama Hamamatsu Shizuoka Japan 4313192
Citazione:
R. Takahira et al., "Dexamethasone attenuates neutrophil infiltration in the rat kidney in ischemia/reperfusion injury: The possible role of nitroxyl", FREE RAD B, 31(6), 2001, pp. 809-815

Abstract

Neutrophil infiltration to the tissue, which is one of the important pathogenetic factors in ischemia/ reperfusion injury, can be inhibited by glucocorticoids. The purpose of the present study was to clarify the mechanisms by which glucocorticoids inhibit neutrophil infiltration in renal ischemia/reperfusion injury in rats. Pretreatment with dexamethasone significantly attenuated the enhanced neutrophil infiltration and expression of intercellular adhesion molecule-1 induced by renal ischemia/reperfusion. Treatment with nitroxyl anion releaser known as Angeli's salt abolished the beneficial effect of dexamethasone in renal ischemia/reperfusion. Renal dysfunction andtubular damage induced by renal ischemia/reperfusion were not ameliorated by pretreatment with dexamthasone. These results indicate that the attenuation by dexamethasone of neutrophil infiltration and intercellular adhesion molecule-1 expression during renal ischemia/reperfusion may be mediated by the suppressed production of nitroxyl anion. Thus, neutrophil infiltration in renal ischemia/reperfusion injury may be mediated, at least in part, by the enhanced production of nitroxyl anion. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:32:50