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Titolo:
Ceramide in apoptosis signaling: Relationship with oxidative stress
Autore:
Andrieu-Abadie, N; Gouaze, V; Salvayre, R; Levade, T;
Indirizzi:
CHU Rangueil, Inst Louis Bugnard, Med Biochem Lab, INSERM,U466, F-31403 Toulouse 4, France CHU Rangueil Toulouse France 4 , INSERM,U466, F-31403 Toulouse 4, France
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 6, volume: 31, anno: 2001,
pagine: 717 - 728
SICI:
0891-5849(20010915)31:6<717:CIASRW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; MANGANESE SUPEROXIDE-DISMUTASE; ELECTRON-TRANSPORT CHAIN; FAS-INDUCED APOPTOSIS; CYTOCHROME-C RELEASE; SMOOTH-MUSCLE CELLS; NEUTRAL SPHINGOMYELINASE; FACTOR-ALPHA; ACID SPHINGOMYELINASE;
Keywords:
ceramide; mitochondria; reactive oxygen species; apoptosis; free radicals;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Andrieu-Abadie, N CHU Rangueil, Inst Louis Bugnard, Med Biochem Lab, INSERM,U466, F-31403 Toulouse 4, France CHU Rangueil Toulouse France 4 1403 Toulouse 4, France
Citazione:
N. Andrieu-Abadie et al., "Ceramide in apoptosis signaling: Relationship with oxidative stress", FREE RAD B, 31(6), 2001, pp. 717-728

Abstract

Ceramide is one of the major sphingosine-based lipid second messengers that is generated in response to various extracellular agents. However, while widespread attention has focused on ceramide as a second messenger involvedin the induction of apoptosis, important issues with regard to the mechanisms of ceramide formation and mode of action remain to be addressed. Several lines of evidence suggest that ceramide and oxidative stress are intimately related in cell death induction. This review focuses on the putative relationships between oxidative stress and sphingolipid metabolism in the apoptotic process and discusses the potential mechanisms that connect and regulate the two phenomena. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:54:52