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Titolo:
Mimicking phosphorylation at Ser-48 strongly reduces surface expression ofhuman macrophage scavenger receptor class A: implications on cell motility
Autore:
Heider, H; Wintergerst, ES;
Indirizzi:
Univ Basel, Inst Biochem, CH-4051 Basel, Switzerland Univ Basel Basel Switzerland CH-4051 Biochem, CH-4051 Basel, Switzerland
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 505, anno: 2001,
pagine: 185 - 190
SICI:
0014-5793(20010907)505:1<185:MPASSR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; MONOCYTE-DERIVED MACROPHAGES; CLASS-A; TRANSGENIC MICE; ATHEROSCLEROSIS; MODELS; LEADS; STATE;
Keywords:
scavenger receptor; macrophage; acetylated low density lipoprotein; cell motility; surface expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Heider, H Univ Basel, Inst Biochem, Vesalgasse 1, CH-4051 Basel, Switzerland Univ Basel Vesalgasse 1 Basel Switzerland CH-4051 , Switzerland
Citazione:
H. Heider e E.S. Wintergerst, "Mimicking phosphorylation at Ser-48 strongly reduces surface expression ofhuman macrophage scavenger receptor class A: implications on cell motility", FEBS LETTER, 505(1), 2001, pp. 185-190

Abstract

The role of human macrophage scavenger receptor Al (SRA1) in the development of atherosclerotic lesions is still scarcely defined. Substituting serine 48 in human SRA1 by an aspartate demonstrated that (1) surface expressionof the mutated receptor was 13-fold decreased; (2) the amount of cell-associated Texas red-labeled acetylated low density lipoprotein (LDL) in mutantreceptor-expressing cells was almost threefold reduced; (3) the migration of mutant receptor-transfected cells towards surfaces coated with oxidized LDL decreased by almost 60% compared to cells that were transfected with the wild type receptor. Phosphorylation of the cytoplasm ic part of SRA1 may help to modulate the residence time of macrophages in atherosclerotic lesions. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:46:35