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Titolo:
Methylprednisolone accelerates the resolution of glomerulonephritis by sensitizing mesangial cells to apoptosis
Autore:
Maruyama, K; Kashihara, N; Yamasaki, Y; Sato, M; Sugiyama, H; Okamoto, K; Maeshima, Y; Odawara, M; Sasaki, J; Makino, H;
Indirizzi:
Okayama Univ, Sch Med, Dept Med 3, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 d, Dept Med 3, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Anat 1, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Anat 1, Okayama 7008558, Japan
Titolo Testata:
EXPERIMENTAL NEPHROLOGY
fascicolo: 5, volume: 9, anno: 2001,
pagine: 317 - 326
SICI:
1018-7782(2001)9:5<317:MATROG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; PROLIFERATIVE NEPHRITIS; TRANSCRIPTION FACTOR; IN-VIVO; CRESCENTIC GLOMERULONEPHRITIS; GLUCOCORTICOID RECEPTOR; FUNCTIONAL ANTAGONISM; SIGNAL-TRANSDUCTION; STEROID-THERAPY;
Keywords:
apoptosis; NF-kappa B; methylprednisolone; glomerulonephritis; mesangial cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Yamasaki, Y Okayama Univ, Sch Med, Dept Med 3, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8, Japan
Citazione:
K. Maruyama et al., "Methylprednisolone accelerates the resolution of glomerulonephritis by sensitizing mesangial cells to apoptosis", EXP NEPHROL, 9(5), 2001, pp. 317-326

Abstract

Glucocorticoid has long been used to treat patients with glomerulonephritis because it ameliorates mesangial cell proliferation and proteinuria, in part by suppressing nuclear factor-kappa B (NF-kappaB) activation, which regulates the transcription of various pro-inflammatory genes. Recent evidenceshows that NF-kappaB activation increases the resistance to TNF-alpha -induced apoptosis in mesangial cells. We examined glomerular cell proliferation and apoptosis along with NF-kappaB activation in the Thy-1.1 nephritis model. We also evaluated TNF-alpha -induced apoptosis in cultured mesangial cells. Methylprednisolone treatment ameliorated mesangial hypercellularity in Thy-1.1 nephritis by decreasing proliferating cells and increasing apoptosis in the glomeruli. These effects were associated with suppressed NF-kappaB activation. This in vitro study revealed that treatment with methylprednisolone and TNF-alpha induced cultured mesangial cell apoptosis. These results suggest that methylprednisolone may accelerate the resolution phase of Thy-1.1 nephritis in part by sensitizing mesangial cells to apoptosis. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:43:23