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Titolo:
Frequency response areas of neurons in the mouse inferior colliculus. I. Threshold and tuning characteristics
Autore:
Egorova, M; Ehret, G; Vartanian, I; Esser, KH;
Indirizzi:
Univ Ulm, Dept Neurobiol, D-89069 Ulm, Germany Univ Ulm Ulm Germany D-89069 v Ulm, Dept Neurobiol, D-89069 Ulm, Germany IM Sechenov Evolutionary Physiol & Biochem Inst, Lab Comparat Physiol Sensory Syst, St Petersburg 194223, Russia IM Sechenov Evolutionary Physiol & Biochem Inst St Petersburg Russia 194223
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 140, anno: 2001,
pagine: 145 - 161
SICI:
0014-4819(200109)140:2<145:FRAONI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL COCHLEAR NUCLEUS; AUDITORY-NERVE FIBERS; SINGLE-UNIT RESPONSES; COMBINATION-SENSITIVE NEURONS; SUPERIOR OLIVARY COMPLEX; 2-TONE RATE SUPPRESSION; BIG BROWN BAT; LATERAL LEMNISCUS; BRAIN-STEM; IDENTIFIED NEURONS;
Keywords:
auditory midbrain; frequency tuning; inhibitory areas; inferior colliculus; receptive fields;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
110
Recensione:
Indirizzi per estratti:
Indirizzo: Ehret, G Univ Ulm, Dept Neurobiol, D-89069 Ulm, Germany Univ Ulm Ulm Germany D-89069 pt Neurobiol, D-89069 Ulm, Germany
Citazione:
M. Egorova et al., "Frequency response areas of neurons in the mouse inferior colliculus. I. Threshold and tuning characteristics", EXP BRAIN R, 140(2), 2001, pp. 145-161

Abstract

Excitatory and inhibitory frequency response areas of 130 neurons of the central nucleus of the mouse inferior colliculus (ICC) were mapped by extracellular single-unit recordings and quantitatively evaluated with regard to thresholds, steepness of slopes of excitatory tuning, characteristic frequencies of excitation (CFE), inhibition (CFI), and bandwidths of response areas (sharpness of tuning). Two-tone stimuli were used to determine the shapes of inhibitory response areas. Class I neurons (n=54) had asymmetrical (with regard to the CFE) excitatory and inhibitory response areas, with inhibition above CFE having lower thresholds and covering larger areas than inhibition below CFE. Quantitative relationships between CFE and CFI thresholds,and sharpness of tuning showed that the receptive fields of about two-thirds of these neurons had properties similar to auditory nerve fibers. Class II neurons (n=36) had small symmetrical or tilted excitatory areas of rather constant bandwidths and broad inhibitory areas reaching far into and often through the excitatory area, leading to closed excitatory areas in ten neurons. Class III neurons (n=32) had higher excitatory thresholds and the highest proportions of unilateral inhibitory areas compared with neurons of the other classes. Their excitatory area often widened symmetrically with increasing sound level. Their inhibitory areas did not overlap with the excitatory area. Class IV neurons (n=8) had two branches of excitatory areas (two-CFs(E)) and six of the neurons had a central inhibitory area in addition to the low- and high-frequency inhibitory areas. In most neurons, the shapes of excitatory response areas predicted the shapes of inhibitory areas. Altogether, 15 neurons from all 4 classes had areas of facilitation in addition to inhibitory areas. Facilitation in six class IV neurons occurred between the two branches of the excitatory area. All 130 neurons had large inhibitory areas, 106 of them on both sides of the excitatory area. That is, sound processing in the ICC shows strong inhibitory components. The close relationships between excitatory and inhibitory CFs found here indicate that inhibitory projections to and interactions within the ICC are tonotopically organized comparable to the excitatory ones.

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Documento generato il 28/10/20 alle ore 03:57:57