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Titolo:
Maximum life spans in mice are extended by wild strain alleles
Autore:
Klebanov, S; Astle, CM; Roderick, TH; Flurkey, K; Archer, JR; Chen, JC; Harrison, DE;
Indirizzi:
Jackson Lab, Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor ME USA 04609Jackson Lab, Bar Harbor, ME 04609 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 9, volume: 226, anno: 2001,
pagine: 854 - 859
SICI:
1535-3702(200110)226:9<854:MLSIMA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAENORHABDITIS-ELEGANS; LONGEVITY; REPRODUCTION; SELECTION; EVOLUTION; SURVIVAL; COMPLEX; GROWTH; TRAITS; COST;
Keywords:
anti-aging genes; maximum life span; aging; mice; DNA markers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Harrison, DE Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA Jackson Lab 600 Main St Bar Harbor ME USA 04609 ME 04609 USA
Citazione:
S. Klebanov et al., "Maximum life spans in mice are extended by wild strain alleles", EXP BIOL ME, 226(9), 2001, pp. 854-859

Abstract

The genes that control basic aging mechanisms in mammals are unknown. By using two four-way crosses, each including a strain derived from wild, undomesticated stocks, we identified two quantitative trait loci that extend murine life spans by approximately 10%. In one cross, the longest-lived 18% ofcarriers of the D8Mit171 marker allele from the MOLD/Rk strain, Mus m. molossinus, outlived the longest lived 18% of noncarriers by 129 days (P = 5.4x 10(-5)); in a second cross, carriers of the D10Mit267 allele from the CAST/Ei strain, Mus m. castaneus, outlived noncarriers by 125 days (P = 1.6 x10(-6)). In both crosses, P < 1.0 x 10(-4) is considered significant. Because these life span increases required that all essential biological systems function longer than normal, these alleles most likely retarded basic aging mechanisms in multiple biological systems simultaneously.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 14:24:58