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Titolo:
Reduced oxygen tension increases atrial natriuretic peptide release from atrial cardiocytes
Autore:
Klinger, JR; Pietras, L; Warburton, R; Hill, NS;
Indirizzi:
Rhode Isl Hosp, Div Pulm Sleep & Crit Care Med, Providence, RI 02903 USA Rhode Isl Hosp Providence RI USA 02903 Care Med, Providence, RI 02903 USA Brown Univ, Sch Med, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 niv, Sch Med, Providence, RI 02903 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 9, volume: 226, anno: 2001,
pagine: 847 - 853
SICI:
1535-3702(200110)226:9<847:ROTIAN>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PULMONARY-HYPERTENSION; RAT VENTRICULAR MYOCYTES; CULTURED ATRIAL; CHRONIC HYPOXIA; ANF RELEASE; KINASE-C; SECRETION; HYPERTROPHY; MODULATION; ACTIVATION;
Keywords:
anoxia; atrial natriuretic factor; pulmonary hypertension; heart;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Klinger, JR Rhode Isl Hosp, Div Pulm Sleep & Crit Care Med, 593 Eddy St, Providence, RI 02903 USA Rhode Isl Hosp 593 Eddy St Providence RI USA 02903 I 02903 USA
Citazione:
J.R. Klinger et al., "Reduced oxygen tension increases atrial natriuretic peptide release from atrial cardiocytes", EXP BIOL ME, 226(9), 2001, pp. 847-853

Abstract

To test the hypothesis that reduced oxygen tension stimulates cardiac atrial natriuretic peptide (ANP) secretion, we measured ANP release and expression in neonatal rat atrial and ventricular cardiac myocytes exposed to 45 min and 3, 6, and 24 hr of 3% or 21% oxygen. In atrial cardiocytes, the percentage of increase in culture media ANP concentration from baseline was greater in cells exposed to 3% than in cells exposed to 21% oxygen after 3 hr (814% +/- 52% vs. 567% +/- 33%, P < 0.05) and 6 hr of exposure (1639% +/- 91% vs. 1155% +/- 73%, P < 0.05). No differences in the percentage of increase in culture media ANP concentration was seen at 45 min (284% +/- 27% vs. 201% +/- 16%, P = NS) or 24 hr (2499% +/- 250% vs. 2426% +/- 195%). There was a significant increase in cellular ANP content between 3 and 24 hr in atrial cardiocytes exposed to 21% oxygen (105% +/- 40% vs. 296% +/- 60%, P < 0.05), but not in atrial cardiocytes exposed to 3% oxygen (118% +/- 20% vs.180% +/- 26%, P = NS). Steady-state ANP mRNA levels in atrial cardiocytes were not affected by oxygen tension. In ventricular cardiocytes, oxygen tension did not affect ANP secretion, cellular ANP content, or steady-state ANP mRNA levels. We conclude that reduced oxygen tension increases release ofANP from atrial, but not ventricular cardiocytes and that this mechanism may contribute to the elevation in plasma ANP seen during acute hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:44:36