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Titolo:
Role of nitric oxide in central sympathetic outflow
Autore:
Patel, KP; Li, YF; Hirooka, Y;
Indirizzi:
Univ Nebraska, Med Ctr, Dept Physiol & Biophys, Omaha, NE 68198 USA Univ Nebraska Omaha NE USA 68198 t Physiol & Biophys, Omaha, NE 68198 USA Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka 8128582, JapanKyushu Univ Fukuoka Japan 8128582 Cardiovasc Med, Fukuoka 8128582, Japan
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 9, volume: 226, anno: 2001,
pagine: 814 - 824
SICI:
1535-3702(200110)226:9<814:RONOIC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; NUCLEUS-TRACTUS-SOLITARII; ROSTRAL VENTROLATERAL MEDULLA; NEURONAL NADPH DIAPHORASE; DIABETES-INSIPIDUS RATS; NOS GENE-EXPRESSION; HEART-FAILURE; SUPRAOPTIC NUCLEI; BLOOD-PRESSURE; BRAIN-STEM;
Keywords:
nitric oxide; central nervous system; sympathetic outflow;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Patel, KP Univ Nebraska, Med Ctr, Dept Physiol & Biophys, 984575 Nebraska Med Ctr, Omaha, NE 68198 USA Univ Nebraska 984575 Nebraska Med Ctr Omaha NEUSA 68198 198 USA
Citazione:
K.P. Patel et al., "Role of nitric oxide in central sympathetic outflow", EXP BIOL ME, 226(9), 2001, pp. 814-824

Abstract

The gaseous molecule nitric oxide (NO) plays an important role in cardiovascular homeostasis. It plays this role by its action on both the central and peripheral autonomic nervous systems. In this review, the central rote ofNO in the regulation of sympathetic outflow and subsequent cardiovascular control is examined. After a brief introduction concerning the location of NO synthase (NOS) containing neurons in the central nervous system (CNS), studies that demonstrate the central effect of NO by systemic administrationof NO modulators will be presented. The central effects of NO as assessed by intracerebroventricular, intracisternal, or direct injection within the specific central areas is also discussed. Our studies demonstrating specific medullary and hypothalamic sites involved in sympathetic outflow are summarized. The review will be concluded with a discussion of the role of central NO mechanisms in the altered sympathetic outflow in disease states such as hypertension and heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:20:35