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Titolo:
Rapid increase in bone mineral density in a child with osteoporosis and autoimmune hypoparathyroidism treated with PTH 1-34
Autore:
Koch, CA;
Indirizzi:
NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 docrinol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 6, volume: 109, anno: 2001,
pagine: 350 - 354
SICI:
0947-7349(2001)109:6<350:RIIBMD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARATHYROID-HORMONE; ANTICONVULSANT THERAPY; ANABOLIC ACTIONS; TRABECULAR BONE; DEFICIENCY; PARATHYROID-HORMONE-1-34; HISTOMORPHOMETRY; CALCIUM; TYPE-1; ADULTS;
Keywords:
hypoparathyroidism; osteoporosis; autoimmune polyglandular syndrome; bone densitometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Koch, CA NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bldg 10,Rm 9D42, Bethesda,MD 20892 USA NICHHD Bldg 10,Rm 9D42 Bethesda MD USA 20892 ethesda,MD 20892 USA
Citazione:
C.A. Koch, "Rapid increase in bone mineral density in a child with osteoporosis and autoimmune hypoparathyroidism treated with PTH 1-34", EXP CL E D, 109(6), 2001, pp. 350-354

Abstract

We describe a 16-year-old girl with autoimmune polyglandular syndrome typeI including hypoparathyroidism, who had osteoporosis that improved rapidlywith parathyroid hormone replacement therapy. Patients with hypoparathyroidism usually have high bone mass. Our, patient developed vertebral compression fractures at age 10, shortly after hypoparathyroidism was diagnosed. She continued to have low lumbar bone mass until age 16, when a dual energy x-ray absorptiometry (DEXA) gy revealed a Z score of -2.2 SD. Several factors including decreased physical activity, total body magnesium depletion, and intermittent ketoconazole and short-term prednisone treatment, may have contributed to the development and progression of osteoporosis. Therapy withsynthetic human parathyroid hormone (PTH) 1-34 rapidly normalized lumbar bone mass, as assessed by DEXA..

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Documento generato il 03/06/20 alle ore 09:15:15