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Titolo:
Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis
Autore:
Hermans, C; Petrek, M; Kolek, V; Weynand, B; Pieters, T; Lambert, M; Bernard, A;
Indirizzi:
Univ Catholique Louvain, Fac Med, Unit Ind Toxicol & Occupat Med, Clin Univ St Luc, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Palacky Univ, Dept Immunol, CR-77147 Olomouc, Czech Republic Palacky UnivOlomouc Czech Republic CR-77147 147 Olomouc, Czech Republic Palacky Univ, Dept Resp Med, CR-77147 Olomouc, Czech Republic Palacky Univ Olomouc Czech Republic CR-77147 147 Olomouc, Czech Republic Univ Catholique Louvain, Clin Univ St Luc, Gen Internal Med Unit, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Univ Catholique Louvain, Clin Univ St Luc, Pneumol Unit, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Univ Catholique Louvain, Clin Univ St Luc, Unit Pathol, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 3, volume: 18, anno: 2001,
pagine: 507 - 514
SICI:
0903-1936(200109)18:3<507:SCCP(A>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERSTITIAL LUNG-DISEASE; RESPIRATORY EPITHELIAL PERMEABILITY; ALVEOLAR-CAPILLARY PERMEABILITY; ANGIOTENSIN CONVERTING ENZYME; BRONCHOALVEOLAR LAVAGE; PULMONARY SARCOIDOSIS; POTENTIAL APPLICATIONS; LATEX IMMUNOASSAY; ALBUMIN; TC-99M-DTPA;
Keywords:
air-blood barrier; alveolitis; Clara cell secretory protein (CC16, CC10, CCSP); lung secretory protein; permeability sarcoidosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Hermans, C Univ Catholique Louvain, Fac Med, Unit Ind Toxicol & Occupat Med, Clin Univ St Luc, 30-54 Clos Chapelle Champs, B-1200 Brussels, Belgium Univ Catholique Louvain 30-54 Clos Chapelle Champs Brussels Belgium B-1200
Citazione:
C. Hermans et al., "Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis", EUR RESP J, 18(3), 2001, pp. 507-514

Abstract

To test the hypothesis that sarcoidosis is associated with an intravascular leakage of lung epithelium secretory proteins, the occurrence and determinants in serum of sarcoid patients of CC16, a small size and readily diffusible lung-specific protein of 16 kDa secreted by bronchiolar Clara cells, was investigated. CC16 was measured by a sensitive latex immunoassay in the serum of 117 patients with established sarcoidosis and of 117 healthy subjects matched for age, sex and smoking status. Stepwise regression analysis was used to identify extrapulmonary variables of CC16 changes in serum. These changes were then compared with biochemical and cellular parameters in bronchoalveolar lavage fluid (BALF) as well as with the number of CC16 immunostaining cells on bronchial or pulmonary biopsy samples. CC16 concentration in serum of sarcoid patients was significantly increased, compared to their matched controls (25.9 +/- 16.2 versus 13.9 +/-5.2 mug(. )L(-1)). In nonsmoking patients without significant renal impairment, CC16 in serum increased with the severity of the chest radiograph and computedtomography changes, and was on average 50-100%, higher when parenchymal involvement was present. Sarcoid patients had, however, normal levels of CC16in BALF and an unchanged number of CC16-immunopositive cells in lung biopsy samples, suggesting that an increased secretion of CC16 in the sarcoid lung is very unlikely, and that the elevation of CC16 in sarcoidosis results from an increased intravascular leakage of the protein across the air-bloodbarrier. The present study suggests that CC16 in serum might provide a useful tool to noninvasively evaluate the damage and increased permeability to proteinsof the air-blood barrier associated with sarcoidosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:57:28