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Titolo:
Suppression of food intake induced by corticotropin-releasing factor family in neonatal chicks
Autore:
Zhang, R; Nakanishi, T; Ohgushi, A; Ando, R; Yoshimatsu, T; Denbow, DM; Furuse, M;
Indirizzi:
Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Adv Anim & MarineBioresources, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 neBioresources, Fukuoka 8128581, Japan Virginia Polytech Inst & State Univ, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA Virginia Polytech Inst & State Univ Blacksburg VA USA 24061 VA 24061 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 427, anno: 2001,
pagine: 37 - 41
SICI:
0014-2999(20010907)427:1<37:SOFIIB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; FACTOR CRF RECEPTOR; UROTENSIN-I; BEHAVIORAL-RESPONSES; UROCORTIN; NEUROPEPTIDE; EXPRESSION; CLONING; STRESS; RATS;
Keywords:
urocortin; urotensin I; corticotropin-releasing factor (CRF); food intake; (chick);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Furuse, M Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Adv Anim & MarineBioresources, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 rces, Fukuoka 8128581, Japan
Citazione:
R. Zhang et al., "Suppression of food intake induced by corticotropin-releasing factor family in neonatal chicks", EUR J PHARM, 427(1), 2001, pp. 37-41

Abstract

Corticotropin-releasing factor (CRF), urocortin and urotensin I share amino acid sequences, and they inhibit food intake in mammals. CRF plays a potent role in decreasing food intake in avian species, but the effects of urocortin and urotensin I have not been investigated. Therefore, the effect of these three peptides on food intake in the neonatal chick was compared. In Experiment 1, birds were injected intracerebroventricularly (i.c.v.) with either 0, 0.01, 0.1 or 1 mug of urocortin following a 3-h fast, and food intake was measured for 2 h post-injection. Food intake was suppressed in a dose-dependent manner. Using a similar design in Experiment 2, the effect of urotensin I was investigated. Urotensin I appeared to suppress food intake in neonatal chicks more than urocortin did. In Experiment 3, the efficacy of CRF, urocortin and urotensin I was directly compared using one dose, 0.1 mug. The results indicated that the suppressive effect on food intake was strongest for CRF followed by urotensin 1, then urocortin. These results suggest that the structure of receptors for the CRF family in chicks may be somewhat different than in mammals. (C) 2001 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:45:19