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Titolo:
Determination of dopamine D-4 receptor density in rat striatum using PB12 as a probe
Autore:
Colabufo, NA; Berardi, F; Calo, R; Leopoldo, M; Perrone, R; Tortorella, V;
Indirizzi:
Univ Bari, Dipartimento Farmacochim, I-70126 Bari, Italy Univ Bari Bari Italy I-70126 partimento Farmacochim, I-70126 Bari, Italy
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 427, anno: 2001,
pagine: 1 - 5
SICI:
0014-2999(20010907)427:1<1:DODDRD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 RACLOPRIDE; D4 RECEPTORS; SCHIZOPHRENIA; BRAIN; GENE; EXPRESSION; AFFINITY;
Keywords:
dopamine D-4 receptor; striatum; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Colabufo, NA Univ Bari, Dipartimento Farmacochim, Via Orabona 4, I-70126 Bari, Italy Univ Bari Via Orabona 4 Bari Italy I-70126 70126 Bari, Italy
Citazione:
N.A. Colabufo et al., "Determination of dopamine D-4 receptor density in rat striatum using PB12 as a probe", EUR J PHARM, 427(1), 2001, pp. 1-5

Abstract

N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-tnethoxybenzamide (PB12), a potent and selective dopamine D-4 receptor ligand, was used as a probe for the direct determination of the dopamine D4 receptor density in rat striatum as an alternative to the subtraction method. The experiment was performed using [H-3]spiroperidol to label D-2, D-3 and D-4 receptors and PB12 to determine directly dopamine D-4 receptor specific binding. The determined B-max value was 82 fmol/mg protein. The contribution of the dopamine D4 receptor to the overall population of D-2-like receptors was 63%; however, thisvalue cannot be considered reliable because of the observed difference in the kinetic profiles of D-2, D-3 and D-4 receptors. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:56:03