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Titolo:
Growth and development of children to 4 years of age after repeated antenatal steroid administration
Autore:
Hasbargen, U; Reber, D; Versmold, H; Schulze, A;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Obstet & Gynaecol, Div Neonatol, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 Div Neonatol, D-81377 Munich, Germany Free Univ Berlin, Klinikum Benjamin Franklin, Dept Paediat, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 Paediat, D-12200 Berlin, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PEDIATRICS
fascicolo: 9, volume: 160, anno: 2001,
pagine: 552 - 555
SICI:
0340-6199(200109)160:9<552:GADOCT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOIDS; BIRTH; FETAL;
Keywords:
antenatal steroids; birth weight drug effects; child development drug effects; lung disease epidemiology; prenatal exposure delayed effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Schulze, A Univ Munich, Klinikum Grosshadern, Dept Obstet & Gynaecol, Div Neonatol, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 , Germany
Citazione:
U. Hasbargen et al., "Growth and development of children to 4 years of age after repeated antenatal steroid administration", EUR J PED, 160(9), 2001, pp. 552-555

Abstract

It is common practice to repeat antenatal steroid administration after 7 to 10 days in women who continue to be at risk for preterm delivery. However, safety and efficacy of repeated courses have not been established. Mothers of singleton infants who had more than five courses of betamethasone (80-120 mg cumulative dose) were eligible for this cohort study. Index patients(IP) were compared to concurrent controls who had less than or equal to1 course but were matched for sex and gestational age. Of 35 IP born between 1986 and 1995 in a single perinatal centre, 28 were available for follow-up and could be matched. There was no difference between groups with respect to maternal age and gestational age at delivery. Median gestational age at initial treatment was 26.3 weeks (25th percentile 25.1 weeks, 75th percentile 27.2 weeks) in IP. There was no significant difference between groups in head circumference, length and body weight at birth and at age 4 years. Theability to sit and to walk without assistance and to use two-word phrases was attained at similar ages. The use of glasses or hearing aids, allergies, asthma or recurrent upper respiratory infections were not reported more frequently in IP. Conclusion: this study failed to ascertain adverse long-term effects of repeated antenatal-steroid administration in infants and children to the age of 4 years. In contrast to a similar Australian study, we were unable to demonstrate a lower birth size in expose infants even though our sample size for women with more than five courses and their cumulative doses were larger.

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Documento generato il 27/11/20 alle ore 09:50:47