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Titolo:
Relationships between neuronal cell adhesion molecule and LHRH neurons in the urodele brain: a developmental immunohistochemical study
Autore:
Gianola, S; Clairambault, P; Franzoni, MF;
Indirizzi:
Univ Turin, Lab Anat Comparata, Dipartimento Biol Anim & Uomo, I-10123 Turin, Italy Univ Turin Turin Italy I-10123 to Biol Anim & Uomo, I-10123 Turin, Italy Univ Paris 07, Anat Comparee Lab, Paris 5, France Univ Paris 07 Paris France 5 aris 07, Anat Comparee Lab, Paris 5, France
Titolo Testata:
EUROPEAN JOURNAL OF HISTOCHEMISTRY
fascicolo: 3, volume: 45, anno: 2001,
pagine: 229 - 238
SICI:
1121-760X(2001)45:3<229:RBNCAM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; POLYSIALIC ACID; HORMONE GNRH; ADULT-RAT; EXPRESSION; PLASTICITY; FORMS; NCAM; ANTIBODIES; BINDING;
Keywords:
neural cell adhesion molecules; polysialic acid; LHRH-containing neurons; immunohistochemistry; development; cell migration; urodele amphibians;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Franzoni, MF Univ Turin, Lab Anat Comparata, Dipartimento Biol Anim & Uomo, Via Accademia Albertina 13, I-10123 Turin, Italy Univ Turin Via AccademiaAlbertina 13 Turin Italy I-10123 ly
Citazione:
S. Gianola et al., "Relationships between neuronal cell adhesion molecule and LHRH neurons in the urodele brain: a developmental immunohistochemical study", EUR J HIST, 45(3), 2001, pp. 229-238

Abstract

Polysialic acid (PSA), a homopolymer attached to neural cell adhesion molecule (NCAM) is considered a major hallmark of vertebrate cell migration. Westudied the distribution of PSA-NCAM by immunohistochemistry, during braindevelopment, in two urodele amphibians, Pleurodeles wald and the neotenic newt Ambystoma mexicanum. In both species a gradual increase of immunolabelling was observed throughout the brain from developmental stage 30 to stage52. At the onset of metamorphosis, some differences became evident: in Pleurodeles immunostaining was gradually restricted to the olfactory system while in Ambystoma, PSA-NCAM maintained a more extended distribution (for example throughout the telencephalic walls) suggesting, for the brain of this latter species, a rather preserved neuronal plasticity. The aim of the present work was to correlate the above described PSA-NCAM-immunoreactivity (IR) with the distribution of luteinizing hormone-releasing hormone (LH-RH) containing neurons, which represent a well known example of neural elements migrating from the olfactory placode. LHRH-IR, undetectable till stage 30, was later found together with PSA-NCAM-IR in both the olfactory system and septo-hypothalamic areas. Such observations further support a role of PSA inproviding a migration route toward the establishment of a part, at least, of the urodele LHRH system. The possible functional meaning of the LHRH-containing neurons localized between dorsal and ventral thalamus of Ambystoma,never reported before in this area, almost devoid of PSA-NCAM-IR, is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:03:16