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Titolo:
Stimulation of phagocytosis and free radical production in murine macrophages by 50 Hz electromagnetic fields
Autore:
Simko, M; Droste, S; Kriehuber, R; Weiss, DG;
Indirizzi:
Univ Rostock, Inst Cell Biol & Biosyst Technol, Div Environm Physiol, D-18051 Rostock, Germany Univ Rostock Rostock Germany D-18051 m Physiol, D-18051 Rostock, Germany
Titolo Testata:
EUROPEAN JOURNAL OF CELL BIOLOGY
fascicolo: 8, volume: 80, anno: 2001,
pagine: 562 - 566
SICI:
0171-9335(200108)80:8<562:SOPAFR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CALCIUM OSCILLATIONS; KINASE-C ACTIVATION; MAGNETIC-FIELD; MICRONUCLEUS FORMATION; MEDIATED PHAGOCYTOSIS; CELL LINE; EXPOSURE; DIFFERENTIATION; LYMPHOCYTES; APOPTOSIS;
Keywords:
phagocytosis; electromagnetic fields; free radicals; intracellular transport; TPA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Simko, M Univ Rostock, Inst Cell Biol & Biosyst Technol, Div Environm Physiol, UnivPl 2, D-18051 Rostock, Germany Univ Rostock Univ Pl 2 Rostock Germany D-18051 Rostock, Germany
Citazione:
M. Simko et al., "Stimulation of phagocytosis and free radical production in murine macrophages by 50 Hz electromagnetic fields", EUR J CELL, 80(8), 2001, pp. 562-566

Abstract

Effects of 50 Hz electromagnetic fields on phagocytosis and free radical production were examined in mouse bone marrow-derived macrophages. Macrophages were in vitro exposed to electromagnetic fields using different magneticfield densities (0.5 - 1.5 mT). Short-time exposure (45 min) to electromagnetic fields resulted in significantly increased phagocytic uptake (36.3% +/- 15.1%) as quantified by measuring the internalization rate of latex beads. Stimulation with 1 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) showed the same increased phagocytic activity as 1 mT electromagnetic fields. However, co-exposure to electromagnetic fields and TPA showed no further increase of bead uptake, and therefore we concluded that because of the absence of additive effects, the electromagnetic fields-induced stimulation of mousebone marrow-derived macrophages does not involve the protein kinase C signal transduction pathway. Furthermore, a significant increased superoxide production after exposure to electromagnetic fields was detected.

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Documento generato il 30/03/20 alle ore 19:36:08