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Titolo:
Neuroendocrinology of stress
Autore:
Habib, KE; Gold, PW; Chrousos, GP;
Indirizzi:
NIMH, Clin Neuroendocrinol Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 endocrinol Branch, NIH, Bethesda, MD 20892 USA NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 docrinol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
fascicolo: 3, volume: 30, anno: 2001,
pagine: 695 -
SICI:
0889-8529(200109)30:3<695:NOS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; RECEPTOR MESSENGER-RNA; PITUITARY-ADRENAL AXIS; POTENTIAL CLINICAL IMPLICATIONS; IRRITABLE-BOWEL-SYNDROME; CENTRAL-NERVOUS-SYSTEM; NEUROPEPTIDE-Y; RAT-BRAIN; LOCUS-COERULEUS; HORMONE CRH;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
122
Recensione:
Indirizzi per estratti:
Indirizzo: Habib, KE NIMH, Clin Neuroendocrinol Branch, NIH, Bldg 10,Room 2D-46, Bethesda, MD 20892 USA NIMH Bldg 10,Room 2D-46 Bethesda MD USA 20892 esda, MD 20892 USA
Citazione:
K.E. Habib et al., "Neuroendocrinology of stress", END METAB C, 30(3), 2001, pp. 695

Abstract

Stimuli that are interpreted by the brain as extreme or threatening, regardless of their modality, elicit an immediate stereotypic response characterized by enhanced cognition, affective immobility, vigilance, autonomic arousal, and a global catabolic state. The brain's ability to mobilize this so-called stress response is paralleled by activation of corticotropin-releasing hormone (CRH) in several nuclei, including the hypothalamus, amygdala and locus ceruleus, and stimulation of the locus ceruleus norepinephrine (LC/NE) system in the brain stem. These systems perpetuate one another, interact with several other transmitter systems in the brain and directly activatethe hypothalamic-pituitary-adrenal (HPA) axis and the three components of the autonomic nervous system, namely the sympatho-adrenal, the cranio-sacral parasympathetic, and the enteric nervous systems. The widespread body system responses to stress are discussed, and the implications of aberrant stress system activity on physical and mental health are outlined. Moreover, the promise of nonpeptide CRH type-1 receptor antagonists to directly targetthe stress system in the brain is highlighted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:53:20