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Titolo:
External biliary drainage plus bile acid feeding is not equal to internal drainage in preserving the cellular immunity following prolonged obstructive jaundice
Autore:
Mok, KT; Wang, BW; Chang, HC; Lin, SL;
Indirizzi:
Natl Yang Ming Univ, Vet Gen Hosp Kaohsiung, Dept Surg, Kaohsiung 813, Taiwan Natl Yang Ming Univ Kaohsiung Taiwan 813 ept Surg, Kaohsiung 813, Taiwan Natl Yang Ming Univ, Vet Gen Hosp Kaohsiung, Dept Pathol, Kaohsiung 813, Taiwan Natl Yang Ming Univ Kaohsiung Taiwan 813 t Pathol, Kaohsiung 813, Taiwan
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 9, volume: 46, anno: 2001,
pagine: 1864 - 1870
SICI:
0163-2116(200109)46:9<1864:EBDPBA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETICULOENDOTHELIAL FUNCTION; RATS; ENDOTOXIN; DECOMPRESSION; MICROFLORA; SEPSIS; INJURY; SALTS; CELLS; LIVER;
Keywords:
obstructive jaundice; biliary drainage; bile acid; cellular immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Mok, KT Natl Yang Ming Univ, Vet Gen Hosp Kaohsiung, Dept Surg, 386 Ta Chung 1st Rd, Kaohsiung 813, Taiwan Natl Yang Ming Univ 386 Ta Chung 1st Rd Kaohsiung Taiwan 813 iwan
Citazione:
K.T. Mok et al., "External biliary drainage plus bile acid feeding is not equal to internal drainage in preserving the cellular immunity following prolonged obstructive jaundice", DIG DIS SCI, 46(9), 2001, pp. 1864-1870

Abstract

This study investigates the importance of intestinal bile flow in cellularimmunity. Sprague-Dawley rats undergoing bile duct ligation (BDL) and shamceiliotomy (Sham) for 14 and 21 days were investigated. Experimental animals following BDL were further divided into an external drainage (ED) group,an ED group with rat chow mixed with 2:2:1 cholic acid, chenodeoxycholic acid, and deoxycholic acid ( ED + BF), and an internal drainage (1D) group. Fourteen days later, they were killed and analyzed for spleen lymphocytic [H-3] thymidine uptake (LHU) under mitogen stimulation with phytohemagglutinin, blood biochemistry, hemogram, and liver pathology. In the 14-day BDL experiment, LHU and serum albumin level were decreased in the BDL group (P < 0.05). After drainage, they were not significantly different among sham, ED, ED + BF, and ID groups. In the 21-day BDL experiment, the red cell volumewas decreased (P < 0.05). After drainage, the ED, ED + BF, and ID groups still had a significantly lower LHU than the sham group (P < 0.05). However,the ID group had higher LHU than the ED and ED + BF groups (P < 0.05). TheED + BF group had a slightly higher LHU than the ED group but not statistically significant. Liver pathology returned to normal after drainage in the14-day BDL model. In contrast, the 21-day BDL group had prominent periportal necrosis and developed periportal fibrosis after drainage. The present study reveals the duration of BDL determines the: severity of hepatic damage. In the 14-day BDL groups, all kinds of drainage completely reverse the impaired liver function and cellular immunity. In the 21-day BDL group, 14-day drainage is inadequate for recovery because irreversible pathological changes are found. The; reversal of cellular immunity in ID is better and faster, because it provides a better hepatic functional, nutritional, and hematological recovery besides the presence of primarily secreted bile acids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:08:19