Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Analysis of the postprandial lipid metabolism: Use of a 3-point test
Autore:
Guerci, B; Paul, JL; Hadjadj, S; Durlach, V; Verges, B; Attia, N; Girard-Globa, A; Drouin, P;
Indirizzi:
CHU Nancy, Hop Jeanne Darc, INSERM, Ctr Invest Clin,Serv Diabetol Malad Metab & Malad, F-54201 Toul, France CHU Nancy Toul France F-54201 Malad Metab & Malad, F-54201 Toul, France Univ Paris 11, Fac Pharm, F-92296 Chatenay Malabry, France Univ Paris 11 Chatenay Malabry France F-92296 6 Chatenay Malabry, France Hop Europeen Georges Pompidou, Biochim Lab, AP HP, F-75015 Paris, France Hop Europeen Georges Pompidou Paris France F-75015 F-75015 Paris, France
Titolo Testata:
DIABETES & METABOLISM
fascicolo: 4, volume: 27, anno: 2001,
pagine: 449 - 457
SICI:
1262-3636(200109)27:4<449:AOTPLM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; TRIGLYCERIDE-RICH LIPOPROTEINS; DEPENDENT DIABETIC-PATIENTS; FAT-LOADING TEST; NORMOLIPIDEMIC MEN; RETINYL ESTERS; OBESE PATIENTS; LIPEMIA; PLASMA; ATHEROSCLEROSIS;
Keywords:
postprandial lipemia; oral fat load test; triglyceride-rich lipoproteins; retinyl palmitate; standardization; obesity; type 2 diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Guerci, B CHU Nancy, Hop Jeanne Darc, INSERM, Ctr Invest Clin,Serv Diabetol Malad Metab & Malad, BP 303, F-54201 Toul, France CHU Nancy BP 303 Toul France F-54201 303, F-54201 Toul, France
Citazione:
B. Guerci et al., "Analysis of the postprandial lipid metabolism: Use of a 3-point test", DIABETE MET, 27(4), 2001, pp. 449-457

Abstract

Objectives: The oral fat load tests used to study postprandial lipemia arecomplex and costly and time consuming. A simplified fat load test could bemore convenient and more appropriate in routine clinical practice because of the number of lipid determinations required. Research design and methods: We evaluated the capacity of a postprandial test model that reduced the number of blood samples taken in thirty three normal weight controls and 17 normotriglyceridemic obese patients (study 1), 10 normolipidemic type 2 diabetic patients and 7 healthy controls (study 2), and 10 hyperlipidemic type 2 diabetic patients studied before and after hypolipidemic therapy (study 3). Blood samples were taken before and up to 8hours after giving the oral fat load containing retinol. Triglyceride (TG and retinyl palmitate (RP) concentrations in the plasma, chylomicrons (CM) and non-chylomicron (nCM) fractions were measured. Postprandial lipid responses using conventional area under the curves (AUCc using 5 to 7 lipid determinations) were compared to a 3-point test that uses only three sample points to predict the area under the curve AUCp: triglycerides at TO, triglycerides at average peak-time (T4), and triglycerides at T8). Results: The AUCc and AUCp for triglycerides and retinyl palmitate were highly correlated in each of the groups and whatever the lipid subfraction (r= 0.664 - 0.995, p < 0.0001). When incremental AUC (iAUC) were used, the coefficients of correlation for triglycerides remained highly significant between AUCc and iAUCp (r = 0.718 - 0.979, p < 0.01 - 0.0001). The same trendof differences was found between cases and controls when AUCp was used instead of AUCc. The means of differences between AUCc and AUCp for triglyceride values were small (0.34 - 0.74 mmol/L.h), and the confidence intervals were acceptable considering the range of the AUCs values (5.60 to 79.8 mmol/L.h for plasma triglycerides). Conclusions: We found that data obtained with a simplified model of ALIC using only 3 points to analyse postprandial lipemia are well correlated withthose obtained by conventional ALIC, and that the AUCp allows to the same conclusions as AUCc when healthy subjects were compared to patients with altered postprandial metabolism. Thus AUCp may be a good evaluation of the AUCc, and the simplified 3-point protocol may well be used and suitable for studies on large groups of subjects who are eligible for an oral fat load test.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:06:08