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Titolo:
Endothelial dysfunction and type 2 diabetes Part 1: physiology and methodsfor exploring the endothelial function
Autore:
Guerci, B; Kearney-Schwartz, A; Bohme, P; Zannad, F; Drouin, P;
Indirizzi:
CHU Nancy, Hop Jeanne Darc, Serv Diabetol Malad Metab & Malad Nutr, F-54201 Toul, France CHU Nancy Toul France F-54201 d Metab & Malad Nutr, F-54201 Toul, France CHU Nancy, Hop Jeanne Darc, INSERM, Ctr Invest Clin, F-54201 Toul, France CHU Nancy Toul France F-54201 ERM, Ctr Invest Clin, F-54201 Toul, France
Titolo Testata:
DIABETES & METABOLISM
fascicolo: 4, volume: 27, anno: 2001,
pagine: 425 - 434
SICI:
1262-3636(200109)27:4<425:EDAT2D>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE PRODUCTION; CIRCULATING ADHESION MOLECULES; CONGESTIVE-HEART-FAILURE; SMOOTH-MUSCLE; SHEAR-STRESS; CORONARY ATHEROSCLEROSIS; ESSENTIAL-HYPERTENSION; RESISTANCE VESSELS; E-SELECTIN; DISEASE;
Keywords:
type 2 diabetes mellitus; diabetic angiopathy; endothelium; endothelial function; hyperglycemia; oxidant stress; hyperlipidemia; insulin; insulin resistance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Guerci, B CHU Nancy, Hop Jeanne Darc, Serv Diabetol Malad Metab & Malad Nutr, BP 303, F-54201 Toul, France CHU Nancy BP 303 Toul France F-54201 303, F-54201 Toul, France
Citazione:
B. Guerci et al., "Endothelial dysfunction and type 2 diabetes Part 1: physiology and methodsfor exploring the endothelial function", DIABETE MET, 27(4), 2001, pp. 425-434

Abstract

Coronary artery, cerebrovascular and peripheral vascular disease, are the principal causes of morbidity and mortality in type 2 diabetes mellitus. The accelerated macrovascular disease in type 2 diabetes mellitus is due partly to the increased incidence of cardiovascular risk factors, such as hypertension, obesity and dyslipidemia. Advanced glycation and products, glycoxidised and oxidized low-density lipoproteins and reactive oxygen species linked to hyperglycemia have all been identified in type 2 diabetes mellitus and could accelerate macroangiopathy. Hence, the resistance to insulin is anadditional independent risk factor, in association with oxidant stress, dyslipidemias, and prothrombic/hypofibrinolytic states. The endothelium is a major organ involved by cardiovascular risk factors, such as hypercholesterolemia, hypertension, inflammation, ageing, postmenopausal status, and smoking. Changes in endothelium function may lead to the coronary artery circulation being unable to cope with the increased metabolism of myocardial muscle independently of a reduced coronary artery diameter. The way endothelial function is altered in diabetic patients is not yet fully understood, but the loss of normal endothelial function could be involved in the pathogenesis of diabetic angiopathy, as endothelial dysfuntion is associated with diabetic microangiopathy and macroangiopathy. Finally, recent reports indicate that an improved metabolic control in diabetic patients, whatever the treatment used, is associated with near normalization or restoration of normal endothelial function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 06:10:48