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Titolo:
FR167653, a cytokine-suppressive agent, reduces myocardial ischemia-reperfusion injury in rats
Autore:
Hoshida, S; Yamashita, N; Otsu, K; Hori, M;
Indirizzi:
Osaka Rosai Hosp, Div Cardiol, Sakai, Osaka 5918025, Japan Osaka Rosai Hosp Sakai Osaka Japan 5918025 l, Sakai, Osaka 5918025, Japan Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka, Japan Osaka Univ Suita Osaka Japan ternal Med & Therapeut, Suita, Osaka, Japan
Titolo Testata:
CYTOKINES CELLULAR & MOLECULAR THERAPY
fascicolo: 4, volume: 6, anno: 2000,
pagine: 165 - 170
SICI:
1368-4736(200012)6:4<165:FACARM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ADULT FELINE MYOCARDIUM; FACTOR-ALPHA GENE; INTERLEUKIN-6 SYNTHESIS; ADHESION MOLECULE-1; PROTEIN EXPRESSION; MAP KINASE; ENDOTOXIN; BIOSYNTHESIS; HEART;
Keywords:
CSAID; cytokines; FR167653; myocardial infarction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hoshida, S Osaka Rosai Hosp, Div Cardiol, 1179-3 Nagasone Cho, Sakai, Osaka 5918025, Japan Osaka Rosai Hosp 1179-3 Nagasone Cho Sakai Osaka Japan 5918025
Citazione:
S. Hoshida et al., "FR167653, a cytokine-suppressive agent, reduces myocardial ischemia-reperfusion injury in rats", CYTOK CELL, 6(4), 2000, pp. 165-170

Abstract

FR167653 inhibits the production of inflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) in human monocytes In a dose-dependent manner. We examined the effects of FR167653on the propagation of myocardial infarction resulting from coronary occlusion-reperfusion and the time course of expression of these cytokines in myocardial tissue in rats. Myocardial infarction was induced by coronary ligation for 20 minutes followed by 2 hours of reperfusion. Although hemodynamicparameters did not differ significantly during coronary occlusion-reperfusion, the size of the infarct was significantly reduced by intravenous administration of FR167653 before occlusion (p < 0.01). mRNA levels of IL-1<beta> and TNF-alpha assessed by the reverse-transcriptase polymerase chain reaction method were significantly increased during coronary occlusion-reperfusion in the ischemic myocardium. Treatment with FR167653, however, significantly reduced the increased expression of these cytokines. These results indicate that the expression of inflammatory cytokines increases in the ischemic-reperfused myocardium and that the inhibition of the increased expression of cytokines by FR167653 effectively reduces myocardial ischemia-reperfusion injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:11:58